OR2C1 Activators
Adrenergic receptor agonists like isoproterenol enhance the production of cAMP by stimulating adrenergic receptors. The neurotransmitter 3-Hydroxytyramine, too, via its own receptors, can elevate cAMP, which in turn may impact OR2C1 receptor function. Similarly, adenosine interacts with its receptors to augment cAMP levels, thereby indirectly influencing the activity of the OR2C1 receptor.
The activity of cAMP is tightly regulated by the enzyme phosphodiesterase, which degrades cAMP into its inactive form. Phosphodiesterase inhibitors such as rolipram, zaprinast, BAY 60-7550, and vardenafil block this degradation, leading to sustained levels of cAMP within the cell. This persistent signal can potentiate the signaling through GPCRs such as OR2C1. Substances like cholera toxin and pertussis toxin alter G protein function, leading to increased cAMP and modulating GPCR-mediated pathways, including those involving OR2C1. Glucagon operates through its cognate GPCR to trigger an increase in cAMP, which can affect the signaling properties of receptors like OR2C1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A non-selective beta-adrenergic receptor agonist that increases cAMP levels, which can enhance GPCR signaling including OR2C1. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
While known for its neurotransmitter role, dopamine can influence GPCR activity, including OR2C1 through dopamine receptors affecting cAMP levels. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Through its receptors, adenosine can increase cAMP, which can indirectly activate OR2C1. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Phosphodiesterase inhibitor that prevents cAMP degradation, thus can enhance signaling through OR2C1. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Another phosphodiesterase inhibitor that increases cAMP levels, potentially enhancing OR2C1 activity. | ||||||
Glucagon trifluoroacetic acid salt | 9007-92-5 (free base) | sc-495801 | 1 mg | $480.00 | ||
Hormone that activates GPCRs leading to increased cAMP and can modulate OR2C1 activity. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Modifies G protein signaling, potentially altering cAMP levels and influencing OR2C1 activity. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $526.00 $735.00 $16653.00 | 7 | |
A phosphodiesterase-5 inhibitor that can increase cAMP in some cells, thereby possibly affecting OR2C1 signaling. | ||||||