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OR1N1 Inhibitors

OR1N1 Inhibitors are compounds that modulate the sensory perception abilities of the olfactory receptor OR1N1 by directly inhibiting its ability to bind with its endogenous ligands. These inhibitors work through competitive inhibition, where they occupy the ligand-binding sites on OR1N1, thus preventing the interaction with natural odorant molecules. This mechanism of inhibition is not dependent on the induction of conformational changes in the protein structure but rather on the ability of these inhibitors to mimic the chemical characteristics of the natural ligands. As such, compounds with structural similarities to the odorant molecules that OR1N1 is designed to detect can act as effective inhibitors. This is the case with various aromatic compounds, monoterpenoids, and organic esters known for their distinctive scents and flavors, such as those found in cinnamon, citrus, menthol, and vanilla. By binding to the receptor sites, these inhibitors effectively block the olfactory signaling that would otherwise be triggered by the binding of natural scents, leading to a reduction in the functional activity of OR1N1. The inhibition of OR1N1 by these chemical compounds results in a decreased sensory response, as the receptor's ability to detect and relay information about specific odorants to the brain is compromised. This process is essential for the nuanced perception of smells, and the presence of these inhibitors disrupts the normal olfactory function. The competitive nature of this inhibition suggests that the availability and concentration of these inhibitors relative to the natural ligands significantly influence the extent of OR1N1 inhibition. Since the olfactory receptors, including OR1N1, are highly selective and sensitive to molecular nuances, the inhibitors must closely resemble the natural ligands' structure to effectively compete for the binding sites.

Items 1 to 10 of 11 total

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Acetophenone	98-86-2	sc-239189	5 g	$20.00		(0)
This organic compound is a known ligand for certain olfactory receptors and its presence can competitively inhibit the binding of other odorants to OR1N1, decreasing the receptor's functional activity.
Eugenol	97-53-0	sc-203043 sc-203043A sc-203043B	1 g 100 g 500 g	$32.00 $62.00 $218.00	2	(1)
Eugenol is a phenolic compound that can bind to olfactory receptors, potentially blocking the binding sites for the natural ligands of OR1N1, which leads to a decrease in the receptor's sensory function.
Methyl Salicylate	119-36-8	sc-204802 sc-204802A	250 ml 500 ml	$47.00 $70.00		(1)
This organic ester is known to have an odor and can bind to olfactory receptors. It may functionally inhibit OR1N1 by occupying the binding site and preventing the interaction with its natural odorant ligands.
Isopentyl acetate	123-92-2	sc-250190 sc-250190A	100 ml 500 ml	$107.00 $225.00		(0)
As an ester with a strong odor, it can competitively inhibit OR1N1 by binding to the same receptor sites as the receptor's endogenous ligands, reducing the receptors ability to signal the presence of certain smells.
Cinnamic Aldehyde	104-55-2	sc-294033 sc-294033A	100 g 500 g	$104.00 $228.00		(0)
This organic compound, with a scent characteristic of cinnamon, can interact with olfactory receptors and serve as a competitive inhibitor for OR1N1, preventing the receptor from detecting its specific odorant molecules.
(±)-Citronellal	106-23-0	sc-234400	100 ml	$51.00		(0)
As an aldehyde with a distinctive lemon scent, it may bind to OR1N1, acting as an inhibitor by competing with the receptors natural ligands, thus hindering its olfactory signaling.
D-Limonene	5989-27-5	sc-205283 sc-205283A	100 ml 500 ml	$84.00 $129.00	3	(1)
This monoterpene, commonly found in citrus rinds, can bind to olfactory receptors and may inhibit OR1N1 by competitively blocking the receptor's ligand binding sites.
(±)-Menthol	89-78-1	sc-250299 sc-250299A	100 g 250 g	$39.00 $68.00		(0)
A cyclic terpene alcohol, menthol can interact with olfactory receptors and may indirectly inhibit OR1N1 by competitively binding to its ligand recognition sites.
Anethole	104-46-1	sc-481571A sc-481571	10 g 100 g	$576.00 $316.00		(0)
This aromatic compound, which has a scent similar to licorice, can bind to olfactory receptors, including OR1N1, potentially acting as a competitive inhibitor and reducing the receptor's sensory response.
Geraniol	106-24-1	sc-235242 sc-235242A	25 g 100 g	$45.00 $119.00		(0)
This monoterpenoid and alcohol, which has a sweet odor, can interact with olfactory receptor sites and may inhibit OR1N1 by competing with its natural ligands for binding, thus inhibiting its function.

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OR1N1 Inhibitors

Acetophenone

Eugenol

Methyl Salicylate

Isopentyl acetate

Cinnamic Aldehyde

(±)-Citronellal

D-Limonene

(±)-Menthol

Anethole

Geraniol