OR1I1 Activators
OR1I1 include a variety of compounds that are capable of binding to and activating this olfactory receptor. Citronellal, a monoterpenoid with a lemon scent, can activate OR1I1 by attaching to its ligand-binding domain, leading to a change in receptor conformation and the initiation of a G-protein coupled signaling cascade. Similarly, geraniol, which possesses a rose-like aroma, interacts with OR1I1 in much the same way, binding to the receptor and prompting a series of intracellular events that result in signal transduction. Benzaldehyde, recognized for its almond-like fragrance, also serves as an activator of OR1I1, by binding to the receptor and inducing the G-protein mediated signaling pathway. Isoamyl acetate, with its characteristic banana odor, engages OR1I1 by a similar mechanism, leading to the activation of the receptor and subsequent olfactory signal propagation.
Eugenol, which has a spicy clove scent, and anethole, reminiscent of licorice, both activate OR1I1 by binding to its active site and initiating a G-protein signaling response. The interaction of limonene, a citrus-scented terpene, with OR1I1 also results in receptor activation through G-protein coupling. Methyl salicylate, with its wintergreen aroma, and alpha-pinene, the scent commonly associated with pine, interact with OR1I1 to trigger the G-protein signaling cascade, leading to olfactory perception. Beta-caryophyllene and linalool, known for their presence in various essential oils, also activate OR1I1 by binding to the receptor and initiating the G-protein mediated signaling pathway. Lastly, hexanal, which offers a grassy note, activates OR1I1 by the same mechanism, binding to the receptor and inducing the G-protein coupled signaling pathway, integral for the function of olfactory receptors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal is a monoterpenoid, a class of compounds known to interact with olfactory receptors. OR1I1, being an olfactory receptor, activates in response to specific odorant molecules. Citronellal, with its aldehyde group, can bind to the ligand-binding site of OR1I1, leading to a conformational change and activation of the receptor's G-protein coupled signal transduction. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol, another monoterpenoid, similar to citronellal, can serve as a ligand for olfactory receptors such as OR1I1. Upon binding to OR1I1, geraniol triggers the associated G-protein signaling cascade, resulting in the activation of the receptor and subsequent neuronal response indicative of olfactory stimulation. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate is an ester commonly described as having a banana-like odor, which is detected by certain olfactory receptors. When isoamyl acetate binds to OR1I1, it can activate the receptor through the G-protein pathway, resulting in the transmission of olfactory signals. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol, a phenylpropene, is known for its presence in clove oil and its ability to activate certain olfactory receptors. Interaction of eugenol with OR1I1 leads to activation through the typical G-protein coupled receptor mechanism, which is fundamental to the function of olfactory receptors. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $565.00 $310.00 | ||
Anethole is a compound with a licorice-like smell, recognized by various olfactory receptors. Binding of anethole to OR1I1 causes receptor activation by stimulating the G-protein signaling pathway, which is crucial for the propagation of olfactory signals. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
Limonene, a prominent terpene found in citrus oils, is known to interact with olfactory receptors. It can activate OR1I1 by binding to the receptor, inducing a G-protein mediated response that culminates in the initiation of olfactory signal transduction. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate, often associated with the scent of wintergreen, can be an activator for specific olfactory receptors like OR1I1. Activation occurs when methyl salicylate binds to OR1I1, enabling the receptor to initiate the G-protein signaling cascade characteristic of olfactory detection processes. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $51.00 $113.00 | 2 | |
Alpha-Pinene, a bicyclic monoterpene found in pine and other coniferous plants, is detectable by olfactory receptors. Interaction with OR1I1 leads to receptor activation as alpha-pinene binds to the receptor's active site, prompting the G-protein coupled signaling pathway that results in olfactory perception. | ||||||
(−)-trans-Caryophyllene | 87-44-5 | sc-251281 sc-251281A sc-251281B sc-251281C | 1 ml 5 ml 25 ml 1 L | $79.00 $157.00 $437.00 $2861.00 | 1 | |
Beta-Caryophyllene, a sesquiterpene commonly found in essential oils, can activate olfactory receptors such as OR1I1. Upon binding to the receptor, beta-caryophyllene initiates G-protein signaling, resulting in the activation of OR1I1 and the consequent olfactory response. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool, a terpene alcohol with a floral scent, known to activate olfactory receptors. OR1I1 can be activated by linalool through its binding to the receptor's specific site, leading to G-protein activation and the transmission of the olfactory signal. | ||||||