OR10A2 Activators
OR10A2 protein engage in various interactions with sensory neuron ion channels, which lead to a cascade of intracellular events culminating in the activation of the olfactory signaling pathways. Icilin, menthol, and thymol primarily target the transient receptor potential melastatin 8 (TRPM8) channel. Upon activation by these chemicals, TRPM8 facilitates an influx of calcium ions into the olfactory sensory neurons. This increase in intracellular calcium is a crucial step that activates the OR10A2 protein, allowing it to participate in the transduction of olfactory signals. Similarly, capsaicin and cinnamaldehyde are known to activate the transient receptor potential vanilloid 1 (TRPV1) and the transient receptor potential ankyrin 1 (TRPA1) channels, respectively. Activation of these channels by the corresponding chemicals also results in an elevation of intracellular calcium levels, which is a pivotal factor for the activation of the OR10A2 protein in the olfactory signaling process.
Moreover, eugenol, anethole, camphor, and thymol can influence various transient receptor potential (TRP) channels, leading to an alteration in the ion dynamics within sensory neurons. This modulation typically results in an increased calcium concentration within the cells, thereby enhancing the activation of the OR10A2 protein. Citral, geraniol, and limonene also have the capacity to modulate ion channel activity, thereby influencing the excitability of olfactory sensory neurons. This modulation facilitates the activation of the OR10A2 protein, which is integral to the olfactory perception mechanism. Patchouli alcohol, while less well-characterized, is believed to interact with ion channels in a manner that similarly leads to the increased intracellular calcium necessary for the activation of the OR10A2 protein, thus playing a role in the olfactory signal transduction pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $91.00 $257.00 | 9 | |
Icilin activates the transient receptor potential melastatin 8 (TRPM8) channel, which can lead to an increase in intracellular calcium levels. Elevated calcium may trigger the activation of OR10A2 by promoting olfactory signal transduction. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol is known to interact with various ion channels in the sensory neurons. By modulating ion channels, eugenol could enhance the influx of ions, potentially leading to the activation of OR10A2 as part of the olfactory signaling cascade. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol is a TRPM8 agonist that, similar to icilin, can increase intracellular calcium concentration. This rise in calcium can activate the signaling pathways in olfactory sensory neurons, potentially leading to the activation of OR10A2. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1 channels, causing an influx of calcium ions. This can indirectly lead to the activation of OR10A2 by increasing the general excitability of olfactory sensory neurons, which may enhance OR10A2-mediated responses. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde activates TRPA1 channels leading to calcium influx in sensory neurons. This activation can enhance the olfactory signaling pathway, possibly leading to the functional activation of OR10A2. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole modulates TRP channels and can lead to increased intracellular calcium. This can enhance olfactory signaling pathways, thereby leading to the functional activation of OR10A2 in olfactory sensory neurons. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral modulates ion channels in sensory neurons. Through this action, it can lead to an increased excitability of the neurons and potentially enhance the activation of OR10A2 as part of the olfactory signal transduction process. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol affects ion channel activity and can lead to increased neuronal excitability. This action can, in turn, lead to the functional activation of OR10A2 through the olfactory signaling pathways it is involved in. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene is known to influence ion channels in olfactory neurons. By altering ion channel dynamics, limonene could lead to the functional activation of OR10A2 through the enhancement of olfactory signal transduction mechanisms. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol impacts ion channel function, particularly TRPM8 and TRPV3 channels, leading to a potential increase in intracellular calcium. This ion influx can activate olfactory signaling pathways that could lead to the activation of OR10A2. | ||||||