Olfr994 Activators
Olfr996, a specific target protein in the olfactory system, plays a crucial role in the perception of odorants within the sensory neurons. This receptor is part of the olfactory receptor family, which is responsible for detecting a wide range of odor molecules in the environment. Olfr996 is expressed on the cell membranes of olfactory sensory neurons located in the nasal epithelium, where it serves as a sensory transducer. Its function is to initiate the olfactory signal transduction cascade upon binding with odorant molecules, leading to the generation of electrical signals that are then transmitted to the brain for further processing. The general mechanism of activation of Olfr996 involves a highly specialized and selective interaction with odorant molecules. When volatile odorants are inhaled, they enter the nasal cavity and come into contact with the olfactory sensory neurons. Each olfactory sensory neuron typically expresses a specific olfactory receptor, such as Olfr996. The activation process begins with the binding of an odorant molecule to the olfactory receptor. This binding event triggers a conformational change in the receptor protein, leading to the activation of intracellular signaling pathways.
Upon activation, Olfr996 initiates a cascade of events that ultimately result in the depolarization of the olfactory sensory neuron. This depolarization generates action potentials that travel along the axon of the neuron, eventually reaching the olfactory bulb in the brain. There, the information is processed and integrated to form the perception of the detected odor. The specificity of Olfr996 for particular odorants is crucial for the discrimination and recognition of different scents, as each olfactory receptor is finely tuned to respond to a specific set of odorant molecules. This remarkable selectivity allows for the diverse range of odors in the environment to be distinguished and perceived by the human olfactory system. In conclusion, Olfr996 is a pivotal player in the olfactory system, responsible for detecting and transducing the signals from odorant molecules into neural impulses. Its activation involves the specific binding of odorants, initiating a series of intracellular events that culminate in the transmission of olfactory information to the brain. The exquisite specificity of Olfr996 for particular odorants is essential for our ability to perceive and distinguish the myriad of scents that surround us, making it a crucial component of the complex olfactory process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr994 by binding to its orthosteric site, causing a conformational change that facilitates G-protein coupling. This activation leads to adenylate cyclase stimulation, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr994. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate activates Olfr994 by binding to specific sites on the receptor, causing a conformational rearrangement. This rearrangement facilitates G-protein interaction and adenylate cyclase activation, increasing cyclic AMP production, leading to PKA activation and functional activation of Olfr994. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral activates Olfr994 through allosteric modulation, altering its conformation to enable effective G-protein coupling. This stimulates adenylate cyclase, elevating cyclic AMP levels, and activating PKA, thereby functionally activating Olfr994. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool activates Olfr994 by interacting with its ligand-binding domain, causing a structural change. This change leads to G-protein activation and adenylate cyclase stimulation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr994. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol activates Olfr994 by binding directly to the receptor, inducing a conformational change. This stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, increased cyclic AMP levels, and subsequent PKA activation, thereby functionally activating Olfr994. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol activates Olfr994 through its interaction with specific binding sites, inducing structural alterations. These alterations facilitate G-protein coupling, leading to adenylate cyclase stimulation, increased cyclic AMP production, and PKA activation, functionally activating Olfr994. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol activates Olfr994 through allosteric modulation, altering the receptor's conformation. This alteration leads to G-protein coupling and activation, stimulating adenylate cyclase, increasing cyclic AMP levels, and activating PKA, thereby functionally activating Olfr994. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $50.00 | ||
Ethyl hexanoate activates Olfr994 by binding to its orthosteric site, inducing a conformational change in the receptor. This leads to G-protein coupling, adenylate cyclase activation, increased cyclic AMP production, and PKA activation, functionally activating Olfr994. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $29.00 $58.00 | ||
Heptaldehyde activates Olfr994 through direct interaction with its binding domain, triggering a structural change. This change enables G-protein coupling and adenylate cyclase activation, increasing cyclic AMP production and PKA activation, thereby functionally activating Olfr994. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $25.00 $33.00 | ||
Octanal activates Olfr994 by interacting with specific binding sites on the receptor, leading to a conformational shift. This shift facilitates G-protein coupling and activation, triggering adenylate cyclase, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr994. | ||||||