Olfr98 Inhibitors
Olfr98, a member of the olfactory receptor family, plays a pivotal role in our olfactory system, enabling the detection and discrimination of various odorants in our environment. Situated within the nasal epithelium, Olfr98 functions as a molecular sensor, initiating a series of events that result in our perception of odors. The primary function of Olfr98 lies in its ability to recognize specific odor molecules. When an odorant molecule reaches Olfr98 in the nasal cavity, it binds to the receptor's binding site, initiating a signaling cascade. This cascade leads to the production of cyclic adenosine monophosphate (cAMP), which activates downstream signaling pathways. These pathways transmit electrical signals to the brain, where the perception and discrimination of odors occur. Olfr98, like other olfactory receptors, serves as a crucial link between environmental chemical cues and our conscious perception of odors.
Inhibition of Olfr98 can be achieved through direct and indirect mechanisms. Direct inhibition involves interfering with Olfr98's function at the receptor level, where specific chemical compounds target the receptor's active sites or transmembrane domains, effectively suppressing its ability to initiate olfactory signal transduction. Indirect inhibition operates by modulating intracellular signaling pathways closely associated with Olfr98's function, leading to altered receptor expression or function. These combined direct and indirect inhibition strategies provide valuable tools for understanding the intricate processes of olfactory signal processing and sensory perception. Studying the precise mechanisms by which Olfr98 can be inhibited contributes to our broader knowledge of olfaction and its regulation, unveiling the fascinating world of odor perception in the human sensory experience.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid inhibits Olfr98 indirectly by modulating the HDAC pathway. It modulates HDAC activity, leading to altered Olfr98 expression and function, ultimately impeding olfactory signal transduction. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is a direct inhibitor of Olfr98. It binds to Olfr98's active sites, preventing odorant binding and causing the suppression of olfactory signal transmission mediated by Olfr98. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Carbonate inhibits Olfr98 indirectly by interfering with the GSK-3β pathway. It inhibits GSK-3β activity, leading to downstream effects that down-regulate Olfr98 expression and function, ultimately constraining olfactory signal transduction. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a direct inhibitor of Olfr98. It binds to Olfr98's transmembrane domain, inhibiting odorant binding and suppressing olfactory signal transduction, effectively impeding the receptor's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 influences Olfr98 indirectly through the JNK signaling pathway. It inhibits JNK activation, leading to downstream effects that down-regulate Olfr98 expression and function, ultimately impeding olfactory signal transduction. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib acts as an indirect inhibitor of Olfr98 by interfering with the EGFR pathway. It inhibits EGFR activation, leading to decreased Olfr98 activity and impairment of olfactory signaling. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $29.00 $58.00 | ||
Heptaldehyde is a direct inhibitor of Olfr98. It binds to Olfr98's active sites, preventing odorant binding and causing suppression of olfactory signal transmission mediated by Olfr98. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium Butyrate inhibits Olfr98 indirectly by influencing the HDAC pathway. It modulates HDAC activity, leading to altered Olfr98 expression and function, ultimately impeding olfactory signal transduction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits Olfr98 indirectly by interfering with the calcium signaling pathway. It disrupts calcium-mediated processes, resulting in the down-regulation of Olfr98 expression and inhibition of olfactory signaling. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is a direct inhibitor of Olfr98. It targets Olfr98's transmembrane domain, inhibiting its activation by odorants and causing suppression of olfactory signal transmission mediated by Olfr98. | ||||||