Olfr98 Activators
Olfr98 is an integral member of the olfactory receptor family, specifically classified as a G protein-coupled receptor (GPCR). These receptors are predominantly expressed in the olfactory epithelium and are crucial for the sense of smell. Olfr98's primary function is to detect and respond to specific odorant molecules, a process that is essential for the perception of a wide range of scents. The activation of Olfr98 by odorant molecules leads to a cascade of intracellular signaling events, culminating in the generation of a neural signal that is interpreted by the brain as a distinct smell. This functionality is not only important for the sensory experience but also plays a vital role in behaviors related to survival, such as locating food, identifying potential dangers, and social interactions.
The mechanism of Olfr98 activation involves several key steps, starting with the binding of an odorant molecule to the receptor. This binding induces a conformational change in Olfr98, which is critical for activating the receptor. The activated Olfr98 then interacts with a G protein located on the inner surface of the cell membrane. This interaction leads to the exchange of GDP for GTP on the G protein's alpha subunit, subsequently activating the G protein. The activated G protein stimulates adenylate cyclase, catalyzing the conversion of ATP to cyclic AMP (cAMP). The increase in cAMP levels activates protein kinase A (PKA), which phosphorylates various proteins, including ion channels. The phosphorylation of these channels results in their opening, leading to changes in the cell's membrane potential. This change generates a neural signal that is transmitted to the brain and interpreted as a specific scent. The specificity of this process, from ligand binding to neural signal generation, highlights the complexity and precision of the olfactory signaling pathway. This pathway is crucial for an organism's ability to detect and differentiate a vast array of odorant molecules, playing a significant role in survival and various behavioral responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Propanol | 67-63-0 | sc-391000C sc-391000 sc-391000B sc-391000A | 1 ml 25 ml 100 ml 500 ml | $32.00 $52.00 $62.00 $87.00 | 1 | |
2-Propanol binds to Olfr98, resulting in the activation of the receptor and initiation of its specific signaling pathway, leading to downstream cellular responses. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
Limonene interacts with Olfr98, activating the receptor through a conformational change which then propagates the signal through its specific signaling pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $51.00 $113.00 | 2 | |
α-Pinene binds to and activates Olfr98, which leads to a series of reactions in the signaling pathway associated with this receptor, resulting in a cellular response. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $43.00 | 2 | |
1,8-Cineole activates Olfr98 by binding to its ligand-binding domain, causing a change in the receptor's structure and initiating its signaling pathway. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol activates Olfr98 through binding to the receptor, causing a conformational shift that initiates the signaling pathway of the receptor. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol binds to Olfr98, activating the receptor and leading to the initiation of its associated signaling mechanisms. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol activates Olfr98 by interacting with its ligand-binding domain, inducing a structural change that triggers the activation of the receptor's signaling pathway. | ||||||