Olfr970 Inhibitors
Olfr970, also known as Olfactory Receptor 970, is a specialized protein involved in the olfactory system, particularly in the perception of odorants. This receptor plays a crucial role in detecting specific odor molecules in the environment. Olfr970 is expressed in olfactory sensory neurons and is responsible for triggering a cascade of cellular events upon binding to its ligands. Its activation initiates signal transduction pathways that ultimately lead to the perception of odor. The inhibition of Olfr970 is of interest in various scientific investigations. To inhibit Olfr970, several chemicals have been identified, as listed in the table above. These chemicals target specific cellular pathways that indirectly downregulate Olfr970 expression and function. For example, compounds like Resveratrol and Curcumin influence the Nrf2 and NF-κB pathways, respectively, leading to reduced Olfr970 expression. Similarly, Quercetin and EGCG affect the JAK-STAT and PI3K-AKT pathways, respectively, resulting in Olfr970 inhibition.
Other compounds like Berberine and 6-Shogaol modulate the AMPK and Wnt pathways, leading to downstream effects on Olfr970. Baicalein, Genistein, Rutin, Silibinin, Dihydroartemisinin, and Andrographolide target various signaling pathways, such as MAPK, ERK, p38 MAPK, mTOR, and STAT3, influencing Olfr970 expression and function. In summary, Olfr970 is a crucial player in the olfactory system, responsible for odor perception. Its inhibition is achievable through the modulation of specific cellular pathways by various chemicals. These inhibitors indirectly downregulate Olfr970 expression, providing valuable insights into the understanding of olfaction and its potential applications in various scientific research areas.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol found in red grapes, inhibits Olfr970 indirectly by modulating the Nrf2 pathway, reducing oxidative stress, which negatively affects Olfr970 expression and function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, indirectly inhibits Olfr970 by suppressing the NF-κB pathway, which is involved in Olfr970 regulation. It downregulates Olfr970 expression via this pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is an indirect inhibitor of Olfr970 that influences the JAK-STAT pathway. It can reduce Olfr970 expression by interfering with the STAT signaling cascade, negatively impacting its function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) inhibits Olfr970 indirectly through the PI3K-AKT pathway. By inhibiting this pathway, EGCG can downregulate Olfr970 expression, leading to inhibition of its function. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine acts as an indirect inhibitor of Olfr970 by targeting the AMPK pathway. It alters the cellular energy balance, which influences Olfr970 expression and function, resulting in inhibition. | ||||||
[6]-Shogaol | 555-66-8 | sc-473881 | 10 mg | $396.00 | ||
[6]-Shogaol indirectly inhibits Olfr970 by affecting the Wnt pathway. It modulates Wnt signaling, which can lead to downregulation of Olfr970 expression and consequent inhibition of its function. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein indirectly inhibits Olfr970 by interfering with the MAPK pathway. By modulating this pathway, it can reduce Olfr970 expression, leading to inhibition of its function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an indirect inhibitor of Olfr970 that affects the ERK signaling pathway. It can downregulate Olfr970 expression by modulating this pathway, resulting in inhibition of its function. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $57.00 $72.00 $126.00 | 7 | |
Rutin indirectly inhibits Olfr970 through the p38 MAPK pathway. By modulating this pathway, it can reduce Olfr970 expression, leading to the inhibition of its function. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silybin acts as an indirect inhibitor of Olfr970 by targeting the mTOR pathway. It can disrupt mTOR signaling, which negatively influences Olfr970 expression and function, resulting in inhibition. | ||||||