Olfr93 Inhibitors
Olfr93, a member of the olfactory receptor gene family, is a pivotal component in the perception of odors in Mus musculus (house mouse). As a G-protein-coupled receptor (GPCR), Olfr93 is responsible for recognizing and transducing odorant signals. This receptor shares the characteristic structure of GPCRs, including a single coding-exon gene and a 7-transmembrane domain.
Inhibition of Olfr93 can be achieved through various chemicals that target key pathways involved in olfactory signal transduction. These chemicals disrupt processes such as GPCR signaling, cAMP-dependent signaling, calcium signaling, and downstream effectors. For example, L-cis Diltiazem modulates voltage-gated calcium channels, indirectly affecting calcium influx and impairing Olfr93's function. Pertussis Toxin interferes with G-protein signaling pathways, resulting in decreased Olfr93 function. H-89 inhibits protein kinase A (PKA), affecting cAMP-dependent signaling and Olfr93's response to odorants. These inhibitors collectively contribute to the modulation of olfactory perception by targeting various aspects of the olfactory signal transduction pathway, offering valuable insights into the intricate regulation of Olfr93 and related pathways in odorant perception in mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride inhibits Olfr93 by modulating ion channels involved in olfactory signal transduction. It disrupts ion flow and reduces the receptor's ability to respond to odorant molecules, leading to a decrease in olfactory perception. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin targets the endoplasmic reticulum calcium pump, indirectly impacting Olfr93 via the calcium signaling pathway. Disruption of calcium homeostasis reduces Olfr93's ability to transmit odorant signals, resulting in decreased olfactory perception. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin inhibits Olfr93 by interfering with G-protein signaling pathways. It ADP-ribosylates specific G-proteins, indirectly suppressing Olfr93 function, and reducing the perception of odorant molecules in the olfactory system. | ||||||
myo-Inositol | 87-89-8 | sc-202714 sc-202714A sc-202714B sc-202714C | 100 g 250 g 1 kg 5 kg | $80.00 $151.00 $275.00 $837.00 | ||
myo-Inositol modulates intracellular calcium release, indirectly impacting Olfr93 through the calcium signaling pathway. It disrupts calcium levels and reduces Olfr93's ability to transmit odorant signals, resulting in a decreased olfactory perception. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $85.00 | 20 | |
Gallein inhibits Olfr93 by targeting the phospholipase C signaling pathway. It disrupts downstream signaling events, indirectly suppressing Olfr93 function, and subsequently reducing the perception of odorant molecules. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol indirectly inhibits Olfr93 by modulating intracellular signaling pathways. It affects downstream events that impact Olfr93 function, leading to a reduced response to odorant stimuli and diminished olfactory perception. | ||||||
U-73343 | 142878-12-4 | sc-201422 sc-201422A | 5 mg 25 mg | $93.00 $350.00 | 17 | |
U73343 inhibits Olfr93 by targeting the phospholipase C signaling pathway. It disrupts downstream signaling events, indirectly suppressing Olfr93 function, and subsequently reducing the perception of odorant molecules. | ||||||