Olfr926 Inhibitors
Olfr926, a member of the olfactory receptor gene family, plays a vital role in the perception of odors in Mus musculus (house mouse). This G-protein-coupled receptor (GPCR) is responsible for recognizing and transducing odorant signals. The olfactory receptor gene family is characterized by single coding-exon genes and a 7-transmembrane domain structure shared with other neurotransmitter and hormone receptors. Olfr926's nomenclature in this organism distinguishes it as a key player in olfaction.
Inhibition of Olfr926 can be achieved through various chemicals that target crucial pathways involved in olfactory signal transduction. These chemicals disrupt processes such as GPCR signaling, cAMP-dependent signaling, calcium signaling, and downstream effectors. L-cis Diltiazem, for example, modulates voltage-gated calcium channels, indirectly affecting calcium influx and impairing Olfr926's function. Pertussis Toxin interferes with G-protein signaling pathways, leading to reduced Olfr926 function. H-89 inhibits protein kinase A (PKA), affecting cAMP-dependent signaling and Olfr926's response to odorants. These inhibitors collectively contribute to the modulation of olfactory perception by targeting various aspects of the olfactory signal transduction pathway, offering valuable insights into the intricate regulation of Olfr926 and related pathways in odorant perception in mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride inhibits Olfr926 by modulating ion channels involved in olfactory signal transduction. It disrupts ion flow and reduces the receptor's ability to respond to odorant molecules, leading to a decrease in olfactory perception. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin targets the endoplasmic reticulum calcium pump, indirectly impacting Olfr926 via the calcium signaling pathway. Disruption of calcium homeostasis reduces Olfr926's ability to transmit odorant signals, resulting in decreased olfactory perception. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin inhibits Olfr926 by interfering with G-protein signaling pathways. It ADP-ribosylates specific G-proteins, indirectly suppressing Olfr926 function, and reducing the perception of odorant molecules in the olfactory system. | ||||||
myo-Inositol | 87-89-8 | sc-202714 sc-202714A sc-202714B sc-202714C | 100 g 250 g 1 kg 5 kg | $80.00 $151.00 $275.00 $837.00 | ||
myo-Inositol modulates intracellular calcium release, indirectly impacting Olfr926 through the calcium signaling pathway. It disrupts calcium levels and reduces Olfr926's ability to transmit odorant signals, resulting in a decreased olfactory perception. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $85.00 | 20 | |
Gallein inhibits Olfr926 by targeting the phospholipase C signaling pathway. It disrupts downstream signaling events, indirectly suppressing Olfr926 function, and subsequently reducing the perception of odorant molecules. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol indirectly inhibits Olfr926 by modulating intracellular signaling pathways. It affects downstream events that impact Olfr926 function, leading to a reduced response to odorant stimuli and diminished olfactory perception. | ||||||
U-73343 | 142878-12-4 | sc-201422 sc-201422A | 5 mg 25 mg | $93.00 $350.00 | 17 | |
U73343 inhibits Olfr926 by targeting the phospholipase C signaling pathway. It disrupts downstream signaling events, indirectly suppressing Olfr926 function, and subsequently reduc | ||||||