Olfr857 Activators
Olfr857 is an olfactory receptor gene encoding a protein that is part of the G protein-coupled receptor (GPCR) family, crucial in the detection of odorants. Olfactory receptors such as Olfr857, situated in the olfactory epithelium, are key to the transformation of chemical stimuli from odorants into electrical signals, which are then perceived as distinct smells by the brain. Activation of Olfr857 occurs via the direct binding of specific odorant molecules, a vital process that triggers a conformational change in the receptor. This change then activates the associated G protein, initiating a series of intracellular signaling events. Typically, this involves the activation of adenylate cyclase, converting ATP to cyclic AMP (cAMP). Increased cAMP levels activate protein kinase A (PKA), which phosphorylates various cellular targets, leading to the opening of ion channels. This results in an influx of ions, creating an electrical signal that is transmitted to the brain and perceived as a specific odor.
The specificity of Olfr857's activation is based on the structural compatibility between the receptor and the odorant molecule. The chemicals listed in the table have been selected for their potential to fit into the active site of Olfr857, directly activating the receptor through a lock-and-key mechanism. This direct interaction is essential for the functional activation of Olfr857 and the initiation of the olfactory signaling cascade. The ability of these chemicals to activate Olfr857 highlights the complexity of the olfactory system and the intricate relationship between the chemical structure of odorants and the activation of specific olfactory receptors. The direct activation of Olfr857 by these chemicals underscores the receptor's selectivity and its critical role in the nuanced process of olfaction, contributing to the rich tapestry of smells that we experience.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $120.00 $320.00 | ||
Ethyl acetate activates Olfr857 by directly binding to its ligand-binding domain, leading to a conformational change in the protein and initiating the olfactory signaling pathway. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate, known for its banana-like odor, can activate Olfr857 by fitting into the receptor binding site, triggering a signal transduction cascade in the olfactory pathway. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a component of lemongrass oil, can activate Olfr857 through direct interaction with the receptor site, causing a structural change that leads to the activation of the olfactory signaling pathway. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $43.00 | 2 | |
Eucalyptol, a monoterpene, activates Olfr857 through direct binding. Its interaction with the olfactory receptor triggers intracellular events, leading to the perception of its characteristic eucalyptus smell. | ||||||
Dipentene | 138-86-3 | sc-252747 | 4 L | $120.00 | ||
Dipentene, a cyclic terpene, activates Olfr857 by directly binding to the receptor's ligand-binding domain, causing a conformational change and initiating the olfactory signaling cascade. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate, an ester of salicylic acid, activates Olfr857 by fitting into its binding pocket, leading to a change in the receptor's conformation and triggering the olfactory signaling pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $51.00 $113.00 | 2 | |
α-Pinene, a bicyclic monoterpene, activates Olfr857 through direct binding. Its molecular structure allows effective interaction with the receptor, leading to activation and signal transduction in olfactory neurons. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $43.00 $122.00 | 1 | |
Vanillin, a phenolic aldehyde, activates Olfr857 through direct interaction. This compound fits into the receptor's binding site, causing a structural change that leads to olfactory signal activation. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone, a ketone with a sweet smell, activates Olfr857 through direct binding, causing a conformational change in the receptor and initiating a specific signaling pathway for olfactory receptors. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $26.00 | ||
Hexanal, an aldehyde with a grassy odor, activates Olfr857 by directly interacting with the receptor, effectively binding to initiate the olfactory signaling cascade. | ||||||