Olfr733 Inhibitors
Olfr733, a member of the olfactory receptor family 4 subfamily N (OR4N), is a vital component of the olfactory system in Mus musculus (house mouse). Like other olfactory receptors, Olfr733 belongs to the family of G-protein-coupled receptors (GPCRs) characterized by a 7-transmembrane domain structure. Its primary function revolves around the recognition and interaction with odorant molecules within the nasal cavity, initiating a cascade of neuronal responses that culminate in the perception of specific odors.
The inhibition of Olfr733 can be achieved through various chemical compounds, both directly and indirectly. Direct inhibitors, such as Menthol and Octanal, bind directly to the receptor, interfering with its ability to recognize specific odorants. In contrast, indirect inhibitors, like Thapsigargin and Forskolin, exert their influence through modulation of intracellular calcium levels and cAMP-dependent signaling pathways. These indirect mechanisms can alter Olfr733's responses to odorants, potentially affecting the perception of various scents. Understanding the inhibition of Olfr733 sheds light on the intricate workings of the olfactory system in house mice, emphasizing the role of specific chemicals and signaling pathways in modulating sensory perception. This knowledge enhances our understanding of the complex processes involved in odorant recognition and transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol is a direct inhibitor of Olfr733, capable of binding to the receptor and interfering with the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of menthol-like scents. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is an indirect inhibitor that inhibits the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump, leading to an increase in intracellular calcium levels and potentially influencing Olfr733's responses to odorants through altered calcium signaling. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal is a direct inhibitor of Olfr733, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of orange-like scents. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an indirect inhibitor that blocks calcium channels, potentially influencing neuronal responses and modulating Olfr733's function in perceiving odorants. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate is a direct inhibitor of Olfr733, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of banana-like scents. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is an indirect inhibitor that activates transient receptor potential vanilloid 1 (TRPV1) channels, influencing neuronal responses and potentially modulating Olfr733's function in perceiving odorants. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is an indirect inhibitor that inhibits phosphoinositide 3-kinase (PI3K) and can influence Olfr733's responses to odorants through alterations in the PI3K signaling pathway. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is a direct inhibitor of Olfr733, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of citrus-like scents. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is an indirect inhibitor that promotes calcium influx, potentially influencing Olfr733's responses to odorants through increased intracellular calcium levels and activation of calcium-dependent signaling pathways. This modulation indirectly impacts sensory perception by altering the intracellular environment. | ||||||