Olfr731 Inhibitors
Olfr731, a member of the olfactory receptor family 4 subfamily K (OR4K), is a crucial component of the olfactory system in Mus musculus (house mouse). Like other olfactory receptors, Olfr731 belongs to the family of G-protein-coupled receptors (GPCRs), characterized by their 7-transmembrane domain structure. Its primary function is to recognize and interact with odorant molecules in the nasal cavity, setting in motion a cascade of neuronal responses that ultimately lead to the perception of specific odors. The inhibition of Olfr731 can be achieved through a variety of chemical compounds, both direct and indirect in their actions. Direct inhibitors, such as Menthol and Vanillin, bind directly to the receptor, hindering its ability to recognize specific odorants. In contrast, indirect inhibitors, like SKF 96365 and KN-93, exert their influence by modulating intracellular signaling pathways and calcium-dependent processes. These alterations can indirectly affect Olfr731's responses to odorants, potentially impacting the perception of various scents.
Understanding the inhibition of Olfr731 sheds light on the intricate mechanisms underlying olfaction in house mice. It highlights the role of specific chemicals and signaling pathways in modulating sensory perception, providing insights into how the olfactory system functions. This knowledge contributes to our broader understanding of olfaction in mammals and enhances our comprehension of the complex processes involved in odorant recognition and transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $40.00 | 2 | |
Menthol is a direct inhibitor of Olfr731, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of menthol-like scents. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF 96365 is an indirect inhibitor that blocks transient receptor potential (TRP) channels, affecting calcium influx. This modulation indirectly influences Olfr731's responses to odorants through alterations in intracellular calcium levels, potentially impacting the perception of various scents. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $43.00 $122.00 | 1 | |
Vanillin is a direct inhibitor that interacts with Olfr731, obstructing the binding of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of vanilla-like aromas. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is an indirect inhibitor that inhibits calmodulin-dependent protein kinase II (CaMKII), influencing calcium-dependent signaling pathways. This indirect modulation can potentially impact Olfr731's responses to odorants, affecting sensory perception through cross-talk with calcium-mediated pathways. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin is an indirect inhibitor that disrupts the mevalonate pathway, potentially altering membrane composition and indirectly affecting Olfr731's functionality. Changes in membrane composition can impact receptor function and odorant perception. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an indirect inhibitor that interferes with intracellular calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump. This disruption indirectly influences Olfr731 by altering calcium-dependent signaling pathways, potentially affecting odorant perception. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is an indirect inhibitor that blocks beta-adrenergic receptors, potentially influencing neuronal responses and modulating Olfr731's function in perceiving odorants. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D is an indirect inhibitor that disrupts actin polymerization and cellular structure. This disruption indirectly influences Olfr731 by altering the organization of cellular components involved in receptor function, potentially impacting odorant perception. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal is a direct inhibitor of Olfr731, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of citrus-like scents. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine is an indirect inhibitor that blocks certain types of ion channels, potentially influencing neuronal excitability and signal transduction pathways. This modulation indirectly impacts Olfr731's responses to odorants, affecting sensory perception through alterations in ion channel activity. | ||||||