Olfr456 Activators
Chemical activators of Olfr456, such as Hexanal, Limonene, and Citral, interact directly with the ligand-binding domain of the protein. These chemicals induce conformational changes in Olfr456, crucial for activating the G-protein coupled receptor (GPCR) pathway. Upon binding of these activators, there is a stimulation of adenylate cyclase, leading to an elevation in intracellular cyclic AMP (cAMP) levels. This increase in cAMP activates protein kinase A (PKA) and other downstream signaling molecules, resulting in various cellular responses.
The range of chemicals, including Eugenol, Menthol, and Geranyl acetate, share a similar mechanism in activating Olfr456. They bind to specific sites on the protein, initiating a cascade of intracellular events. This binding not only alters the protein conformation but also effectively triggers the GPCR pathway. The activation of this pathway leads to a series of intracellular reactions, primarily the production of cAMP. This signaling molecule plays a central role in activating downstream effectors, thus propagating the signal initiated by the chemical activators. The downstream effects of these signaling pathways culminate in physiological responses, demonstrating the direct impact these chemical activators have on the functional activity of Olfr456.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal activates Olfr456 by binding directly to its ligand-binding domain, triggering a conformational change that initiates signal transduction via G-protein coupled receptors, leading to increased intracellular cAMP levels and subsequent cellular responses. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene serves as a direct activator of Olfr456 by interacting with its specific odorant binding site. This interaction causes allosteric modulation of Olfr456, activating adenylate cyclase through G-protein signaling and increasing cAMP levels, leading to downstream cellular effects. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral activates Olfr456 through direct binding to its odorant recognition site, promoting the activation of the G-protein coupled receptor pathway, enhancing cAMP production, and activating protein kinase A, which propagates signal transduction processes. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol selectively activates Olfr456 by binding to its odorant binding domain, enhancing G-protein coupling and activating adenylate cyclase, resulting in elevated cAMP levels and initiating a cascade of intracellular signaling events. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol directly activates Olfr456 by interacting with its ligand-binding domain, triggering a signaling cascade through G-protein activation, leading to stimulation of adenylate cyclase, increased cAMP levels, and activation of downstream signaling pathways. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate activates Olfr456 by directly interacting with its ligand-binding site, inducing a conformational change that facilitates the activation of the G-protein coupled receptor pathway, increasing cAMP, and activating subsequent signaling mechanisms. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene acts as a direct activator of Olfr456 by engaging with its odorant binding site, prompting a conformational change, which activates G-protein signaling cascades, leading to elevated levels of cAMP and the activation of downstream cellular pathways. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin activates Olfr456 by binding to its specific odorant receptor site, inducing a conformational alteration in the protein structure. This change triggers the activation of G-protein signaling, enhancing cAMP production and activating downstream effector molecules. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $63.00 $53.00 | ||
Isoeugenol activates Olfr456 by interacting with its specific odorant binding domain, facilitating the activation of G-protein coupled receptor pathways, increasing cAMP levels, and activating downstream signaling pathways, including protein kinase A activation. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal directly activates Olfr456 by binding to its ligand recognition site, triggering a conformational change that leads to G-protein signaling pathways activation, an increase in intracellular cAMP levels, and subsequent activation of a series of downstream cellular responses. | ||||||