Olfr456 Inhibitors
Olfr456, a key member of the olfactory receptor gene family, plays a crucial role in initiating neuronal responses that lead to the perception of various smells. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Olfr456 is intricately involved in recognizing and transducing signals from odorant molecules within the nasal cavity. The gene family's unique single coding-exon genes and independent nomenclature underscore the complexity and distinctiveness of Olfr456 within the genome.
Inhibition of Olfr456 involves a sophisticated interplay of direct and indirect mechanisms, each intricately influencing the receptor's function. Direct inhibitors, such as Camphor and Menthol, disrupt the binding of odorant molecules to Olfr456, impairing G protein-mediated transduction and resulting in altered neuronal responses. On the other hand, indirect inhibitors like Rolipram and PD98059 modulate specific cellular pathways associated with Olfr456 function. Rolipram, for instance, affects the cAMP-PKA signaling pathway, leading to altered receptor responsiveness to odorants. Similarly, PD98059 targets the MAPK-ERK signaling pathway, influencing receptor function and diminishing the perception of specific smells. This intricate interplay between direct and indirect inhibitors highlights the multifaceted nature of Olfr456's regulation and its indispensable role in shaping our perception of smells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Indirect inhibitor affecting the cAMP-PKA signaling pathway linked to Olfr456. Modulation of this pathway alters the receptor's responsiveness to odorants, influencing G protein-mediated transduction and ultimately impacting the perception of specific smells. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Direct inhibitor altering ion channels related to olfactory signal transduction. This disruption influences Olfr456 responsiveness to odorants, impairing G protein-mediated transduction and resulting in diminished neuronal responses and altered smell perception. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $59.00 | 2 | |
Indirect inhibitor disrupting cellular metabolism and ATP synthesis pathways linked to Olfr456. Altered energy supply hampers signal transduction, leading to impaired functionality of the olfactory receptor and diminishing the perception of specific odorants. | ||||||
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $41.00 | 2 | |
Direct inhibitor interacting with Olfr456, impeding odorant binding and disrupting G protein-mediated transduction. This interference results in altered neuronal responses, diminishing the overall perception of smells associated with Olfr456 activation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Indirect inhibitor targeting the MAPK-ERK signaling pathway associated with Olfr456. Modulation of this pathway influences receptor function, altering the responsiveness to odorants and impairing G protein-mediated transduction, leading to diminished smell perception. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Direct inhibitor affecting ion channels involved in olfactory signal transduction. Disruption of ion flow influences Olfr456 responsiveness to odorants, impairing G protein-mediated transduction and resulting in altered neuronal responses and diminished smell perception. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Indirect inhibitor influencing the NF-κB signaling pathway linked to Olfr456. Modulation of this pathway alters receptor function, impacting G protein-mediated transduction and diminishing the perception of specific odorants through changes in cellular processes. | ||||||
Isoflurane | 26675-46-7 | sc-470926 sc-470926A | 5 g 25 g | $69.00 $219.00 | 7 | |
Direct inhibitor interacting with Olfr456, disrupting odorant binding and impairing G protein-mediated transduction. This interference leads to altered neuronal responses, diminishing the overall perception of smells associated with Olfr456 activation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Indirect inhibitor influencing the JNK signaling pathway associated with Olfr456. Modulation of this pathway alters receptor function, impairing G protein-mediated transduction and diminishing the perception of specific odorants through changes in cellular processes. | ||||||