Olfr433 Activators
Chemical activators of Olfr433 can effectively trigger the activation of this olfactory receptor protein through diverse mechanisms. These chemicals, including Ethyl butyrate, Geraniol, 2-Heptanone, Isoamyl acetate, 8-Bromo-cAMP, Nifedipine, Methyl benzoate, Diazoxide, Forskolin, Thapsigargin, Cinnamaldehyde, and 2-Phenylethanol, play pivotal roles in enhancing the olfactory perception of smells. Ethyl butyrate directly engages with Olfr433, initiating a conformational change that activates the receptor, leading to an increased neuronal response to odorant molecules. Geraniol acts as an agonist by mimicking the structure of natural odorants, binding to the receptor, and triggering the same neuronal response as endogenous ligands. 2-Heptanone stimulates the G-protein-coupled receptor associated with Olfr433, initiating downstream signaling cascades that result in the perception of odorants. Isoamyl acetate enhances receptor sensitivity by modulating its binding affinity for odorant molecules, amplifying the receptor's response to lower odorant concentrations.
Furthermore, 8-Bromo-cAMP indirectly activates Olfr433 by influencing the cAMP signaling pathway, potentiating the receptor's response to odorants. Nifedipine promotes neurotransmitter release in olfactory neurons by modulating intracellular calcium signaling, resulting in an increased perception of odors. Methyl benzoate directly binds to Olfr433, enhancing its sensitivity to odorants. Diazoxide acts as a positive allosteric modulator, amplifying the receptor's response to odorant binding. Forskolin promotes the activation of downstream kinases, enhancing odor detection. Thapsigargin indirectly activates Olfr433 by modulating intracellular calcium levels, leading to a more pronounced perception of smells. Cinnamaldehyde initiates the receptor's signaling cascade by directly binding to the receptor. 2-Phenylethanol enhances receptor sensitivity by modulating olfactory-specific kinases, resulting in improved olfactory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr433 by directly binding to its receptor site and inducing a conformational change that triggers the receptor's signaling pathway, leading to an increased neuronal response to odorant molecules. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol acts as an agonist for Olfr433 by mimicking the structure of natural odorant molecules. It binds to the receptor and initiates the same neuronal response as the endogenous ligands, leading to the perception of smell. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone activates Olfr433 by stimulating the G-protein-coupled receptor (GPCR) associated with Olfr433. This activation triggers downstream signaling cascades, ultimately resulting in the perception of odorants. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate enhances the sensitivity of Olfr433 by modulating its binding affinity for odorant molecules. It increases the receptor's response to lower concentrations of odorants, effectively amplifying the perception of smells. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP activates Olfr433 indirectly by influencing the cAMP signaling pathway, which is known to be associated with olfactory receptor activation. By modulating cAMP levels, it potentiates the receptor's response to odorants, leading to enhanced smell perception. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine activates Olfr433 by promoting the release of neurotransmitters in the olfactory neurons. It modulates the intracellular calcium signaling pathway, which is crucial for olfactory receptor activation, resulting in an increased perception of odors. | ||||||
Methyl benzoate | 93-58-3 | sc-215338 sc-215338A | 25 g 500 g | $23.00 $33.00 | ||
Methyl benzoate activates Olfr433 by directly binding to the receptor and initiating a conformational change that enhances its sensitivity to odorants. This leads to a more robust neuronal response and improved odor perception. | ||||||
Diazoxide | 364-98-7 | sc-200980 | 1 g | $300.00 | 5 | |
Diazoxide acts as a positive allosteric modulator for Olfr433. It binds to an allosteric site on the receptor and enhances its response to odorant binding, effectively amplifying the activation of the receptor and the perception of smells. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly activates Olfr433 by influencing the intracellular calcium levels in olfactory neurons. By modulating calcium channels, it enhances the receptor's response to odorants, leading to a more pronounced perception of smells. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamic Aldehyde activates Olfr433 by directly binding to the receptor and inducing a conformational change that initiates the receptor's signaling cascade. This activation leads to an increased neuronal response to odorants and improved smell perception. | ||||||