Olfr433 Inhibitors
The Olfr433 olfactory receptor, a crucial member of the G-protein-coupled receptor (GPCR) family, plays a pivotal role in initiating neuronal responses that lead to the perception of smell. Possessing a 7-transmembrane domain structure, Olfr433 actively participates in the recognition and G protein-mediated transduction of odorant signals, contributing significantly to the intricate network of olfactory perception.
The inhibition of Olfr433 involves a sophisticated interplay of direct and indirect mechanisms. Direct inhibitors, such as menthol, terpinolene, cineole, 1,8-cineole, butanoic acid, and camphene, disrupt Olfr433's 7-transmembrane domain structure, impeding the receptor's ability to transduce odorant signals through G protein-mediated pathways. On the other hand, indirect inhibitors, including ethyl acetate, hexanoic acid, isoamyl acetate, anisaldehyde, and benzaldehyde, modulate the cyclic nucleotide signaling pathway associated with Olfr433. Their influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. This diverse array of inhibitors provides a comprehensive strategy for interfering with Olfr433's role in odor recognition, offering avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial for confirming the efficacy of these inhibitors in practice and unraveling the complexities of olfactory signal transduction mediated by Olfr433.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $40.00 | 2 | |
Menthol serves as a direct inhibitor, binding to Olfr433 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $120.00 $320.00 | ||
Ethyl acetate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr433. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $43.00 | 2 | |
Cineole serves as a direct inhibitor, binding to Olfr433 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr433. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
4-Methoxybenzaldehyde | 123-11-5 | sc-238884 sc-238884A sc-238884B sc-238884C | 5 g 100 g 250 g 1 kg | $29.00 $41.00 $71.00 $122.00 | ||
4-Methoxybenzaldehyde acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr433. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Butyric acid serves as a direct inhibitor, binding to Olfr433 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr433. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||