Olfr421 Inhibitors
The Olfr421 olfactory receptor, a key member of the G-protein-coupled receptor (GPCR) family, orchestrates the initiation of neuronal responses essential for the perception of smells. With its 7-transmembrane domain structure, Olfr421 actively participates in the recognition and G protein-mediated transduction of odorant signals, playing a pivotal role in the intricate network of olfactory perception.
The inhibition of Olfr421 involves a nuanced interplay of direct and indirect mechanisms. Direct inhibitors, such as cinnamaldehyde, benzaldehyde, anethole, 2-phenylethanol, eucalyptol, and citronellol, act by binding to Olfr421 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. On the other hand, indirect inhibitors, including geranyl acetate, allyl isothiocyanate, octanal, methyl salicylate, and isoamyl acetate, modulate the cyclic nucleotide signaling pathway associated with Olfr421. Their influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. This diverse array of inhibitors provides a comprehensive approach to disrupting Olfr421's role in odor recognition, offering avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial to confirming the efficacy of these inhibitors in practice and further unraveling the intricacies of olfactory signal transduction mediated by Olfr421.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamic Aldehyde serves as a direct inhibitor, binding to Olfr421 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr421. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $44.00 $67.00 $119.00 | 3 | |
Allyl isothiocyanate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr421. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
trans-Anethole | 4180-23-8 | sc-253727 | 1 ml | $28.00 | 1 | |
trans-Anethole serves as a direct inhibitor, binding to Olfr421 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr421. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol functions as a direct inhibitor, binding to Olfr421 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr421. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
Eucalyptol serves as a direct inhibitor, binding to Olfr421 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr421. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
(±)-β-Citronellol functions as a direct inhibitor, binding to Olfr421 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||