Olfr372 Activators
Chemical activators of Or2z8, a G-protein-coupled receptor involved in olfactory perception, are diverse yet exhibit a common mechanism of action. Compounds like Isoeugenol, Geraniol, and Benzyl acetate directly bind to specific domains of Or2z8, such as the GPCR and ligand-binding domains. This binding triggers crucial conformational changes in the receptor, which are imperative for its activation. These changes facilitate the receptor's ability to transduce olfactory signals through G protein-coupled pathways. The specificity of this interaction underscores the role of these activators in enhancing the receptor's sensitivity and response to various odorants.
Other activators, including Citronellol, Phenethyl alcohol, and Linalool, further demonstrate this mechanism. By binding to different regions of Or2z8, these chemicals induce structural alterations that lead to the functional activation of the receptor. This activation is vital for initiating G protein-coupled odorant signal transduction processes. Additionally, chemicals like Alpha-Pinene, Citral, Vanillin, and Ethyl vanillin engage with the receptor's structure, resulting in conformational changes that potentiate its olfactory signal transduction capabilities. Methyl salicylate and Limonene complete this set, emphasizing the direct activation of Or2z8 through specific interactions with its olfactory receptor domain. Each of these chemicals contributes to the functional activation of Or2z8 by influencing its structural and conformational dynamics, which are crucial for effective olfactory signal transduction and perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $62.00 $52.00 | ||
Isoeugenol activates Or2z8 by binding to its GPCR domain, leading to a conformational change in the receptor. This activation initiates G protein-mediated signal transduction specifically for olfactory perception. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol activates Or2z8 through direct interaction with its ligand-binding domain, inducing structural changes that facilitate the transduction of olfactory signals via G protein-coupled pathways. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $29.00 | 1 | |
Benzyl acetate binds to the active site of Or2z8, causing a conformational alteration that triggers the receptor's activation and subsequent G protein-mediated olfactory signal transduction. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
(±)-β-Citronellol activates Or2z8 by engaging with its extracellular domain, inducing a structural change that leads to G protein-coupled intracellular signaling related to olfaction. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol interacts with Or2z8, activating it by altering its conformation, thereby enhancing the receptor's ability to initiate olfactory signal transduction. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool binds to Or2z8, inducing a conformational shift that activates the receptor and initiates G protein-coupled odorant signal transduction processes. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $51.00 $113.00 | 2 | |
Alpha-Pinene activates Or2z8 by binding to its olfactory receptor domain, triggering a structural change that facilitates G protein-mediated olfactory signal transduction. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral interacts directly with Or2z8, causing a conformational alteration that leads to the activation of G protein-coupled signaling mechanisms specific to olfactory perception. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $43.00 $122.00 | 1 | |
Vanillin activates Or2z8 by engaging with its GPCR structure, inducing a conformational change that enhances the receptor's ability to transduce olfactory signals. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde activates Or2z8 by binding to its ligand-binding region, leading to a structural alteration that facilitates G protein-coupled odorant signal transduction. | ||||||