Olfr371 Activators
Chemical activators of Or10k2, a member of the olfactory receptor protein family, involve a range of compounds that interact specifically with its structure. These activators, such as Dihydrocapsaicin, Allyl isothiocyanate, Eugenol, and Anethole, engage with the receptor's G-protein-coupled receptor (GPCR) structure, triggering a conformational change. This change is crucial for the activation of Or10k2, as it enhances the receptor's ability to recognize and transduce odorant signals. The specific interaction with the GPCR structure is key to their functionality, as it directly influences the receptor's sensitivity and response to specific odorants.
Isoamyl acetate, Cinnamaldehyde, Limonene, and Methyl salicylate activate Or10k2 by binding to different domains of the receptor, such as the ligand-binding or extracellular domains. This binding induces structural alterations in the receptor, enabling the initiation of G protein-coupled odorant signal transduction. These activators play a significant role in facilitating the olfactory signal transduction process by specifically enhancing the receptor's ability to initiate intracellular signaling pathways related to olfaction. Citral, Ethyl vanillin, Vanillin, and Benzaldehyde further demonstrate this principle by inducing conformational shifts in Or10k2, which lead to enhanced olfactory signal transduction. Each of these chemicals contributes to the functional activation of Or10k2 by influencing its structural and conformational dynamics, crucial for effective olfactory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dihydrocapsaicin | 19408-84-5 | sc-202578 sc-202578A | 10 mg 50 mg | $52.00 $156.00 | 1 | |
Dihydrocapsaicin activates Or10k2 by binding to its GPCR structure, triggering a conformational change that results in the activation of downstream signaling pathways. This interaction specifically enhances the receptor's ability to recognize and transduce odorant signals. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $44.00 $67.00 $119.00 | 3 | |
Allyl isothiocyanate interacts directly with Or10k2, facilitating its activation through a mechanism that involves the binding to its olfactory receptor domain. This binding induces a cellular response, effectively enabling the recognition of specific odorants. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates Or10k2 by binding to its extracellular domain, which causes a structural change in the receptor, leading to the activation of G protein-mediated signal transduction pathways specifically related to olfaction. | ||||||
trans-Anethole | 4180-23-8 | sc-253727 | 1 ml | $28.00 | 1 | |
trans-Anethole interacts with Or10k2, activating it by altering its conformation. This interaction enhances the receptor's sensitivity to certain odorants, facilitating the olfactory signal transduction process. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate activates Or10k2 by binding to its active site, which induces a conformational shift in the receptor structure, enabling the initiation of G protein-coupled odorant signal transduction. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde activates Or10k2 by interacting with its ligand-binding domain, promoting a conformational change that triggers G protein-coupled intracellular signaling pathways related to olfactory perception. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene directly activates Or10k2 by binding to its olfactory receptor domain, inducing a change in the receptor's structure that facilitates the transduction of odorant signals through G protein-mediated pathways. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate activates Or10k2 by engaging with its extracellular domain, causing a conformational alteration that leads to the activation of downstream G protein-coupled signaling mechanisms specific to olfactory transduction. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral activates Or10k2 by binding to its olfactory receptor domain, which triggers a structural change in the receptor, leading to the initiation of odorant signal transduction via G protein-coupled pathways. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde activates Or10k2 by interacting with its ligand-binding region, inducing a conformational shift that enhances the receptor's ability to transduce olfactory signals through G protein-mediated pathways. | ||||||