Olfr324 Inhibitors
Olfr324 inhibitors encompass a variety of chemical compounds that, while not directly targeting the receptor, enact their inhibitory effects through the modulation of sensory neuron responses. These agents achieve this by engaging with transient receptor potential (TRP) channels, which are pivotal in the regulation of sensory neuron excitability. For instance, certain compounds can activate TRPM8 and TRPA1 channels, leading to a desensitization of these neurons and a subsequent dampening of olfactory signal transduction, thereby indirectly inhibiting Olfr324. Other molecules exert a similar impact but through different TRP channels, such as TRPV1, whose prolonged activation by specific agonists results in a diminished neuronal capacity to convey olfactory information. This mechanism of desensitization effectively attenuates the functional activity of olfactory receptors by altering the sensory neuron's response to olfactory stimuli, which concomitantly mitigates the signaling through Olfr324.
Furthermore, there are compounds that inhibit various TRP channels, which can also indirectly reduce the sensitivity of Olfr324 by modifying the sensory neuron signaling pathways. The use of antagonists that target TRPA1 channels is a prime example of how the inhibition of these ion channels can lead to decreased neuronal activation and, therefore, a reduced signaling efficacy of Olfr324. Another approach involves antagonists of the TRPV1 receptor, which, by decreasing the excitability of sensory neurons, can lead to an indirect suppression of Olfr324's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $91.00 $257.00 | 9 | |
This synthetic super-agonist of the transient receptor potential (TRP) channels, specifically TRPM8 and TRPA1, can indirectly reduce the sensitivity of Olfr324. Activation of TRP channels leads to sensory neuron stimulation and can modify the perception of olfactory signals. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
As an agonist of TRPV1, a receptor present in sensory neurons, capsaicin can desensitize these neurons and impair their ability to relay olfactory information, thereby indirectly inhibiting the functional activity of Olfr324. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
By activating TRPM8 channels, menthol leads to a cooling sensation and can desensitize sensory neurons, including olfactory neurons, which would indirectly diminish the signaling capacity of Olfr324. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
The compound targets TRPA1 channels that are expressed in sensory neurons. Activation of these channels can modulate the sensory neuron response, potentially reducing the efficacy of olfactory signaling and thereby indirectly inhibiting Olfr324. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
This phenylpropene acts on multiple TRP channels, including TRPV1 and TRPA1. It can alter sensory neuron responses, which may diminish the signal transmission of olfactory receptors such as Olfr324. | ||||||
Allicin | 539-86-6 | sc-202449 sc-202449A | 1 mg 5 mg | $489.00 $1557.00 | 7 | |
Known for activating TRPA1 channels, allicin can influence sensory neuron responses. This may lead to an indirect inhibition of the olfactory receptor Olfr324 by modifying the sensory neuron signaling. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
As an inhibitor of various TRP channels, it can modify sensory neuron responses. By inhibiting these channels, Ruthenium Red can lead to a decrease in the functional activity of olfactory receptors, such as Olfr324. | ||||||
HC-030031 | 349085-38-7 | sc-203994 sc-203994A | 10 mg 50 mg | $89.00 $333.00 | 2 | |
This antagonist of the TRPA1 channel can decrease the sensitivity of sensory neurons, which could indirectly lead to the inhibition of the olfactory receptor Olfr324 by dampening the sensory signaling pathway. | ||||||
A-967079 | 1170613-55-4 | sc-363348 sc-363348A sc-363348B | 5 mg 25 mg 100 mg | $88.00 $372.00 $942.00 | 5 | |
As a selective antagonist of the TRPA1 channel, it can attenuate the sensory neuron signaling and indirectly inhibit the function of Olfr324. | ||||||