Molecular structure of HC-030031, CAS Number: 349085-38-7
HC-030031 (CAS 349085-38-7)
See product citations (2)
Alternate Names:
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
Application:
HC-030031 is a potent and selective TRPA1 inhibitor
CAS Number:
349085-38-7
Purity:
≥98%
Molecular Weight:
355.39
Molecular Formula:
C18H21N5O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
HC-030031 is a substituted theophylline derivative. Potent and selective ANKTM1 (TRPA1) inhibitor. It antagonizes allyl isothiocyanate (AITC)- and formalin-evoked calcium influx with IC50 values of 6.2 and 5.3 muM respectively. Both inward and outward currents elicited by AITC or formalin are rapidly and reversibly blocked by HC-030031 which also blocks the activation of TRPA1 by N-methylmaleimide and by electrophillic prostaglandins2. TRPV1, TRPV3, TRPV4, hERG and NaV1.2 are not blocked.
HC-030031 (CAS 349085-38-7) References
- HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. | Eid, SR., et al. 2008. Mol Pain. 4: 48. PMID: 18954467
- The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation. | da Costa, DSM., et al. 2010. Pain. 148: 431-437. PMID: 20056530
- TRPA1 contributes to cold hypersensitivity. | del Camino, D., et al. 2010. J Neurosci. 30: 15165-74. PMID: 21068322
- Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system. | Pereira, LM., et al. 2013. Eur J Pain. 17: 223-33. PMID: 22689151
- The effect of intrathecal administration TRPA1 antagonists in a rat model of neuropathic pain. | Zhang, W., et al. 2014. Anesth Analg. 119: 179-185. PMID: 24854869
- Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences. | Gupta, R., et al. 2016. Sci Rep. 6: 37460. PMID: 27874100
- Nicotine Evoked Currents in Human Primary Sensory Neurons. | Zhang, X., et al. 2019. J Pain. 20: 810-818. PMID: 30659887
- TRPA1 channel contributes to myocardial ischemia-reperfusion injury. | Conklin, DJ., et al. 2019. Am J Physiol Heart Circ Physiol. 316: H889-H899. PMID: 30735434
- Inhibition of TRPA1 Promotes Cardiac Repair in Mice After Myocardial Infarction. | Li, R., et al. 2020. J Cardiovasc Pharmacol. 75: 240-249. PMID: 31868827
- Inhibition of TRPA1 reduces airway inflammation and hyperresponsiveness in mice with allergic rhinitis. | Fang, Z., et al. 2021. FASEB J. 35: e21428. PMID: 33774861
- Transient receptor potential ankyrin 1 mediates cisplatin-induced apoptosis in renal tubular cells via calcium-dependent signaling pathway. | Meng, X., et al. 2021. Ann Palliat Med. 10: 9025-9038. PMID: 34488389
- Cisplatin induces TRPA1-mediated mechanical allodynia in the oral mucosa. | Nakatomi, C., et al. 2022. Arch Oral Biol. 133: 105317. PMID: 34823152
- Structural Modeling of TRPA1 Ion Channel-Determination of the Binding Site for Antagonists. | Gawalska, A., et al. 2022. Molecules. 27: PMID: 35630553
Inhibitor of:
ANKTM1, MCAT, MrgA1, MrgA2, MrgA3, MrgA4, MrgA6, MrgA8, MrgA9, MrgB1, MrgH, MRGX, Olfr1166, Olfr324, Olfr536, Olfr551, Olfr722, OR2S2, OR2V1, OR51I, PIRT, TRP14, V1RL5, and Vmn2r99.Activator of:
MrgB3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HC-030031, 10 mg | sc-203994 | 10 mg | $89.00 | |||
HC-030031, 50 mg | sc-203994A | 50 mg | $333.00 |