Olfr317 Activators
Chemical activators of Olfr317 can be understood as a diverse group of molecules that share the ability to bind to and initiate a signaling cascade through this specific olfactory receptor. Among these activators, acetophenone, benzaldehyde, and cinnamaldehyde interact with Olfr317 by fitting snugly into its odorant-binding site, which is a specialized pocket designed to accommodate aromatic or volatile compounds. This interaction causes the receptor to change its shape, a process known as a conformational change. This structural rearrangement is not merely a physical alteration but the critical first step in the signaling process, as it enables the subsequent activation of associated G protein-coupled receptor (GPCR) pathways. Following this, a series of intracellular events unfold, which translate the chemical binding into an electrical signal, ultimately perceived as an odor.
Furthermore, molecules like ethyl vanillin, eugenol, and isoeugenol, despite their structural differences, also activate Olfr317 by binding to its ligand-binding domain. This triggers similar conformational changes, underscoring the versatility of the receptor to accommodate various substances and yet initiate a comparable end response. Other activators such as limonene, methyl salicylate, and phenethyl alcohol further illustrate the receptor's broad ligand specificity. Additionally, vanillin, along with alpha-ionone and beta-ionone, engage with Olfr317 in a like manner. These interactions highlight the dynamic nature of the receptor, which is capable of binding to different chemical structures and, through a common mechanism involving conformational changes and the activation of GPCR signaling, ultimately contribute to the perception of a wide range of odors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone, through its aromatic ketone group, can activate Olfr317 by binding to the receptor's odorant binding site, leading to a conformational change that triggers the G protein-coupled receptor signaling cascade, resulting in the receptor's functional activation. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde binds to and activates Olfr317 by fitting into the receptor's ligand-binding domain, which causes a shift in the receptor's conformation, leading to activation of the G protein-coupled signaling mechanisms inherent to olfactory transduction. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
Ethyl vanillin activates Olfr317 by binding to the receptor's ligand-binding site, initiating a conformational change that activates the G protein-coupled intracellular signaling pathway, which is necessary for the transmission of the olfactory signal. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol can activate Olfr317 by binding to the odorant-binding site of the receptor, causing a conformational alteration that triggers the G protein-coupled receptor signaling pathway leading to the receptor's functional activation. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $63.00 $53.00 | ||
Isoeugenol activates Olfr317 by binding to the receptor's ligand-binding domain and inducing a conformational change, which in turn activates the G protein signaling cascade associated with olfactory perception. | ||||||
Dipentene | 138-86-3 | sc-252747 | 4 L | $120.00 | ||
Limonene can activate Olfr317 by interacting with the odorant-binding site, causing a structural change in the receptor that leads to the activation of the downstream signal transduction pathways involved in olfactory detection. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate activates Olfr317 by binding to the receptor's ligand-binding domain, which causes a conformational change that triggers the G protein-coupled receptor signaling pathway, resulting in the receptor's activation. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol can activate Olfr317 by binding to the receptor's odorant site, leading to a structural change that activates the G protein-coupled signaling cascade, crucial for olfactory signal propagation. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin activates Olfr317 by binding to the receptor's ligand-binding site, which initiates a series of structural changes that lead to the activation of the G protein-coupled signaling pathways involved in odor detection. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
Alpha-ionone activates Olfr317 by interacting with the receptor's ligand-binding site, causing a conformational shift that activates the G protein-coupled signal transduction pathway, leading to functional activation of the receptor. | ||||||