Olfr316 Inhibitors
In the nuanced realm of olfactory perception, the functional inhibition of the olfactory receptor Olfr316 is a complex process involving a variety of chemical interactions. Compounds that alter the excitability of sensory neurons, such as those that activate TRPV1 and TRPM8 ion channels, can modulate the perception of odors by initiating a calcium influx leading to neuron desensitization or by inducing a cooling sensation that dampens signal transduction. Similarly, the presence of certain metal ions that block ion channels crucial for olfactory signal propagation directly hinders the activation of Olfr316, preventing the necessary ionic changes for signal initiation. Moreover, substances that interact with protein residues, such as those capable of inactivating sulfhydryl groups, disrupt the receptor's ability to bind odorant molecules, attenuating the initial steps of olfactory signal transduction.
Further intricacies arise from the indirect influences on Olfr316 function through metabolic pathways and intracellular signaling mechanisms. Interference with bitter taste receptor function suggests that cross-modal sensory interactions could extend to olfactory receptors, affecting the intracellular signaling cascades and decreasing Olfr316 activity. Compounds that alter the metabolism of aldehydes or act as oxidizing agents can modify the availability or structure of potential ligands for Olfr316, thereby impeding its functionality. Additionally, the inhibition of energy-dependent processes such as the mitochondrial electron transport chain or the depletion of cytochrome P450 cofactors underscores the complexity of the olfactory receptor's operational environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
This compound binds to and activates the transient receptor potential vanilloid 1 (TRPV1) on sensory neurons, leading to a calcium influx that can desensitize the neurons to subsequent stimuli. The desensitization of these neurons can reduce the perception of odorants by Olfr316 through decreased neural signaling. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
As a TRPM8 agonist, menthol induces a cooling sensation by activating this ion channel, which can modulate sensory perception and potentially dampen the signal transduction of olfactory receptors like Olfr316 due to altered neuronal excitability. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions can bind to and block the ion channels implicated in olfactory signal transduction, thereby directly inhibiting the function of Olfr316 by preventing the necessary ion flow for olfactory receptor activation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Similar to copper, zinc can also bind to and interfere with ion channels in the olfactory system, potentially inhibiting the activation of Olfr316 by disrupting the ionic changes required for olfactory signal propagation. | ||||||
Silver nitrate | 7761-88-8 | sc-203378 sc-203378A sc-203378B | 25 g 100 g 500 g | $114.00 $378.00 $1081.00 | 1 | |
This compound can inactivate sulfhydryl groups on proteins and may directly interact with cysteine residues on olfactory receptors like Olfr316, hindering their ability to bind odorant molecules and initiate signal transduction. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to interfere with bitter taste receptor function, chloroquine could also affect olfactory receptors by altering intracellular signaling, potentially leading to a decreased functional activity of Olfr316 through cross-modal sensory interaction. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
This compound can activate TRPA1 channels, leading to an influx of calcium ions in sensory neurons, which may modulate the neural activity and indirectly result in the inhibition of the olfactory receptor Olfr316. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Inhibits cytochrome c oxidase in the mitochondrial electron transport chain, which could decrease ATP production, thereby indirectly inhibiting energy-dependent processes such as the function of G-protein coupled receptors like Olfr316. | ||||||