Olfr311 Inhibitors
The olfactory receptor Olfr311 is a complex protein that plays a crucial role in the detection of specific odorants. Chemicals that inhibit this receptor function by directly binding to the receptor's active site, preventing interaction with activating odorants. For instance, molecules designed with structural similarity to the natural ligands of Olfr311 can act as antagonists; they occupy the binding site and can alter the receptor's conformation, rendering it unresponsive to odorant signals. Ester compounds, which are often fragrant, are particularly effective at this, binding more efficiently than the natural odorants and thus impairing the receptor's signaling ability. Similarly, certain organic compounds containing aromatic rings can also act as potent inhibitors by competing with natural ligands for binding to Olfr311, thereby inhibiting the olfactory response.
Furthermore, some inhibitors may exert their effect by changing the physical properties of the olfactory receptor. Monocyclic terpene alcohols and aromatic ketones, for example, can bind to Olfr311 and change its conformation, which diminishes the receptor's sensitivity to specific scents. Other inhibitors, like nitroaromatic compounds, interact with the sensory neurons expressing Olfr311 to reduce the overall sensitivity of the receptor.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
This is a phenylpropene, an allyl chain-substituted guaiacol. Eugenol can bind to the odorant binding site of Olfr311, acting as an antagonist and thus inhibiting the receptor's ability to detect specific scent molecules. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
This is an ester that is commonly found in bananas and pears. It can inhibit Olfr311 by binding to the receptor's active site more effectively than the natural odorants, preventing the receptor from sending a proper signal to the brain. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
This simplest aromatic ketone can act as an antagonist to Olfr311. It competes with natural odorants for binding to the active site of the receptor, which inhibits the receptor's normal response to scents. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
This is an organic compound that gives cinnamon its flavor and odor. By binding to the olfactory receptor Olfr311, cinnamaldehyde can act as an inhibitor, blocking the receptor's ability to detect certain odors. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
A monocyclic terpene alcohol that can provide a cooling sensation. Menthol can inhibit Olfr311 by binding to the receptor and changing its conformation, which can reduce the receptor's ability to detect specific odors. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin can inhibit Olfr311 by binding to the receptor and blocking its ability to respond to odorant molecules. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
A prominent compound in the oil of citrus fruit peels. D-Limonene can inhibit the function of Olfr311 by binding to the receptor, preventing the detection of its natural ligand and thus inhibiting the sensory response. | ||||||
trans-Anethole | 4180-23-8 | sc-253727 | 1 ml | $28.00 | 1 | |
Anethole can act as an inhibitor of Olfr311 by competitively binding to the receptor's active site, diminishing the receptor’s ability to respond to olfactory stimuli. | ||||||