Olfr304 Inhibitors
Olfr304 inhibitors consist of a variety of chemical compounds that can impede the functional activity of this specific olfactory receptor through several distinct mechanisms. For instance, some inhibitors work by activating related sensory receptors, such as the transient receptor potential (TRP) channels, which then alters the sensory environment and leads to decreased sensitivity or desensitization of Olfr304. This is exemplified by compounds that elicit sensations of heat or cold upon binding to their respective TRP channels, consequently causing an adaptation effect that diminishes the ability of Olfr304 to detect its specific ligands. Other compounds may directly compete with the natural ligands of Olfr304, binding to the same receptor sites and thereby preventing activation of the receptor. This competitive inhibition is a common method by which the function of olfactory receptors can be suppressed, as it directly blocks the signaling that would normally occur upon ligand binding.
Additionally, some inhibitors may alter the receptor environment or affect the receptor's structural components, which indirectly decreases Olfr304 activity. For instance, certain aromatic compounds have the potential to bind nonspecifically to the olfactory receptors, disrupting their normal function or changing the conformation of the receptor such that it becomes less responsive to its ligands. Similarly, compounds that serve as solvents or fixatives in fragrances might interact with the membrane dynamics of the olfactory epithelium, thereby inhibiting the function of receptors like Olfr304. This type of inhibition results from changes in the physical properties of the receptor's surrounding membrane, which can influence receptor activity and signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $89.00 $252.00 | 9 | |
Agonist of the transient receptor potential melastatin-8 (TRPM8), which can affect the perception of cool temperatures. Inhibition of Olfr304 occurs due to the alteration of temperature sensing, which may impact olfactory signaling. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Activates transient receptor potential vanilloid-1 (TRPV1) leading to a sensation of heat. This activation can cause a decrease in sensitivity of olfactory receptors like Olfr304, through sensory adaptation mechanisms. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $43.00 $66.00 $117.00 | 3 | |
Stimulates the transient receptor potential ankyrin-1 (TRPA1), which is involved in the detection of pungent compounds. This stimulation could desensitize Olfr304 due to overlap in chemical detection pathways. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Acts on the TRPV1 receptor and could modify the sensory environment, leading to a potential decrease in olfactory receptor activation, including that of Olfr304. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
TRPM8 agonist which elicits a cooling sensation and can modulate sensory perception, potentially inhibiting the function of other receptors like Olfr304 by means of sensory interference. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Activates TRPA1 and can modulate sensory pathways, potentially leading to the decreased activity of olfactory receptors such as Olfr304 by causing a shift in sensory processing. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Known to interact with TRPA1 and can potentially inhibit the activation of olfactory receptors like Olfr304 by competing for sensory signaling pathways. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
May interact with specific olfactory receptors and interfere with their activation, thus potentially inhibiting Olfr304 by direct competition for binding sites. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
As an analog of vanillin, it might interfere with olfactory receptor function by binding to receptor sites or altering the receptor environment, leading to a decrease in Olfr304 activity. | ||||||
Diethyl phthalate | 84-66-2 | sc-239738 sc-239738A | 25 ml 500 ml | $26.00 $32.00 | ||
Used as a solvent and fixative in fragrances, it could potentially disrupt normal olfactory receptor function, including the inhibition of Olfr304 by altering membrane dynamics or competing for ligand binding. | ||||||