Olfr1166 Inhibitors
Chemical inhibitors of Olfr1166 can exert their inhibitory effects through various mechanisms, primarily by targeting channels and receptors crucial for the signal transduction process that Olfr1166 is involved in. For instance, Capsazepine and AMG-9810, as selective antagonists of the TRPV1 channel, can inhibit Olfr1166 by preventing the propagation of noxious heat and chemical signals that this channel typically mediates. Similarly, SB-705498 and BCTC, also TRPV1 antagonists, can inhibit the channel's function, thereby obstructing the signal transduction pathway that Olfr1166 likely participates in. Iodo-Resiniferatoxin shares this mechanism of action, offering another means of inhibiting Olfr1166 by impeding TRPV1 activity. JNJ-17203212 provides an additional method to inhibit Olfr1166, as a selective TRPV1 antagonist, further preventing the initiation of the chemical signal transduction pathways essential for Olfr1166's role.
On the other hand, HC-030031 and A-967079 target the TRPA1 receptor, another critical component in chemosensory transduction. By antagonizing TRPA1, these chemicals can functionally inhibit Olfr1166 by disrupting the transduction pathway that relies on calcium influx through this receptor. AP18, a selective TRPA1 antagonist, operates via a similar mechanism, serving to prevent the initiation of intracellular signaling in which TRPA1 and Olfr1166 are involved. Additionally, Ruthenium Red, a polycationic dye that can inhibit calcium channels including TRPV channels, can impair the function of Olfr1166 by blocking the necessary calcium influx crucial for olfactory signal transduction. Lastly, ML204 and SKF-96365, which inhibit TRPC channels, can indirectly inhibit Olfr1166 by altering the neuronal signaling environment and preventing the calcium-mediated signal transduction that is fundamental for Olfr1166's function. These chemical inhibitors, through their respective targets, contribute to the inhibition of Olfr1166 by disrupting the molecular and cellular processes that facilitate chemosensory signal transduction.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $148.00 $459.00 | 11 | |
Capsazepine, a synthetic analogue of capsicum's vanilloid capsaicin, can inhibit Olfr1166 by antagonizing the transient receptor potential vanilloid-1 (TRPV1) channel, which is involved in the detection of noxious chemical stimuli. Inhibition of TRPV1 can disrupt the signal transduction of chemical stimuli, which Olfr1166 is responsible for detecting. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red is a polycationic dye that can inhibit calcium channels including TRPV channels. By inhibiting these channels, it can impair the function of Olfr1166 by preventing the necessary calcium influx that is crucial for the activation of the olfactory signal transduction pathway. | ||||||
HC-030031 | 349085-38-7 | sc-203994 sc-203994A | 10 mg 50 mg | $89.00 $333.00 | 2 | |
HC-030031 is an antagonist of the TRPA1 receptor, another channel involved in chemosensory transduction. Inhibition of TRPA1 can lead to functional inhibition of Olfr1166 by obstructing the transduction pathway that relies on calcium influx through TRPA1. | ||||||
A-967079 | 1170613-55-4 | sc-363348 sc-363348A sc-363348B | 5 mg 25 mg 100 mg | $88.00 $372.00 $942.00 | 5 | |
A-967079 is a selective antagonist of the TRPA1 receptor. By selectively inhibiting TRPA1, it can functionally inhibit Olfr1166 by reducing the receptor's ability to propagate chemical detection signals that might otherwise trigger a cascade in which Olfr1166 participates. | ||||||
AMG-9810 | 545395-94-6 | sc-201477 sc-201477A | 10 mg 50 mg | $86.00 $344.00 | 3 | |
AMG-9810 is a selective TRPV1 antagonist, which can inhibit Olfr1166 by blocking the TRPV1 channel's transduction of noxious heat and chemical signals, thus preventing Olfr1166 from participating in these sensory pathways. | ||||||
JNJ 17203212 | 821768-06-3 | sc-204024 sc-204024A | 10 mg 50 mg | $185.00 $781.00 | ||
JNJ-17203212 is a selective TRPV1 antagonist that can inhibit Olfr1166 by obstructing the TRPV1 channel′s function, thereby halting the chemical signal transduction pathways essential for Olfr1166′s role in chemosensation. | ||||||
4-Methyl-2-(1-piperidinyl)-quinoline | 5465-86-1 | sc-483337 | 25 mg | $430.00 | ||
ML204 is a selective inhibitor of the TRPC4/TRPC5 channels. Although Olfr1166 is not directly linked to TRPC channels, the inhibition of these channels can alter the neuronal signaling environment, potentially inhibiting the intracellular pathways Olfr1166 relies on. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 is an inhibitor of receptor-mediated calcium entry channels, including TRPC channels. By inhibiting these channels, it can indirectly inhibit Olfr1166 by preventing the calcium-mediated signal transduction that is fundamental for the protein's function. | ||||||