Olfr1166 Activators
Chemical activators of Olfr1166 include a variety of aldehydes and terpenoids that initiate signal transduction by specifically binding to the ligand-binding domain of the olfactory receptor. Cyclononasiloxane, octamethyl- is one such activator that, due to its presence in fragrances, can bind to Olfr1166's ligand-binding site, effectuating a conformational change that is essential for signal transduction. Similarly, aldehydes such as Decanal, Nonanal, Heptanal, and Octanal can activate Olfr1166 by engaging with the receptor's active site. These molecules have structural properties that allow them to fit snugly into the receptor's binding pocket, and their binding is the initiating event that triggers a cascade of intracellular signals, culminating in the perception of scent.
The activation of Olfr1166 by terpenoid compounds such as Linalool, Citronellal, Geraniol, Citral, Limonene, Alpha-Pinene, and Beta-Caryophyllene follows a similar pattern. These chemicals, with their distinctive structures, are recognized by Olfr1166 and activate the receptor through direct interaction. For instance, Linalool and Citronellal, with their monoterpenoid backbones, bind to Olfr1166 and trigger olfactory signal transduction, which is a complex process involving G-protein coupled receptor (GPCR) pathways. Geraniol and Citral also participate in this direct activation by engaging with the receptor's binding site, promoting a change that signals downstream molecules to propagate the scent signal. Limonene, Alpha-Pinene, and Beta-Caryophyllene, each with their unique chemical structures, similarly bind to the receptor, inducing an active conformation that leads to signal transduction. The specificity of these interactions underscores the precision with which Olfr1166 can discern and respond to a wide array of scent molecules.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Decanal | 112-31-2 | sc-234518 | 25 g | $43.00 | ||
Decanal is an aldehyde with a strong citrus scent known to activate olfactory receptors, including Olfr1166, by binding specifically to the receptor's active site, leading to its activation and subsequent signaling events. | ||||||
Nonanal | 124-19-6 | sc-257926 | 1 g | $67.00 | ||
Nonanal, another aldehyde with a citrus odor, can activate Olfr1166 through direct interaction with the ligand-binding domain of the receptor, initiating signal transduction mechanisms intrinsic to olfactory signaling. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptanal is an aldehyde that can activate Olfr1166 by binding to its odorant-binding site, triggering the G-protein coupled receptor pathway inherent to the function of this olfactory receptor. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal is a fatty aldehyde that can activate olfactory receptors such as Olfr1166 by fitting into its odorant recognition site, which leads to activation of the receptor and its downstream signaling pathways. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, a naturally occurring terpene alcohol, can activate Olfr1166 by directly binding to the receptor's specific binding site, causing activation and the initiation of olfactory signal transduction. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal, a monoterpenoid with a citrus scent, activates Olfr1166 by direct interaction with the receptor's binding site, which in turn activates the olfactory signal transduction cascade. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, a monoterpenoid alcohol, activates Olfr1166 by binding to its ligand-specific site, which is a key step in the activation of the olfactory receptor and the consequent signaling pathway. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a compound found in the oils of several plants, can activate Olfr1166 through direct binding to the receptor, which causes a conformational change and initiates the signaling process. | ||||||
Dipentene | 138-86-3 | sc-252747 | 4 L | $120.00 | ||
Limonene, a cyclic terpene, can activate Olfr1166 by interacting specifically with its binding site, which leads to activation of the receptor's associated G-protein and signal transduction. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-Pinene, a bicyclic monoterpenoid, activates Olfr1166 by binding to its specific binding site, leading to receptor activation and triggering the downstream signaling events. | ||||||