OCTN2 Activators
OCTN2 Activators are chemical compounds that interact with OCTN2, enhancing its transport function. OCTN2 is a sodium-dependent organic cation/carnitine transporter, and its functional activity can be enhanced by various substrates and drugs known to interact with organic cation transporters. Carnitine, a natural substrate of OCTN2, can enhance its transport activity, and its uptake can be increased by Metformin and Verapamil, thereby enhancing the functional activity of OCTN2.
Primaquine, Quinidine, Pregabalin, Procainamide, Cimetidine, Ranitidine, Furosemide, Pyrilamine, and Nicotine are all known to interact with organic cation transporters, and they can enhance the functional activity of OCTN2 by acting as substrates and promoting transport activity. These chemicals, by virtue of being substrates for OCTN2, increase the transport function of this transporter, enhancing its functional activity. This specific interaction with OCTN2 underscores the importance of the chemicals in enhancing the functional activity of the OCTN2 transporter.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
Carnitine is a natural substrate of OCTN2, which is a sodium-dependent organic cation/carnitine transporter. Increased levels of carnitine can enhance the functional activity of OCTN2 by promoting its transport activity. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin has been shown to increase the uptake of carnitine by upregulating OCTN2, thereby enhancing the functional activity of this transporter. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that can increase the uptake of carnitine via OCTN2, enhancing its transport activity. | ||||||
8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline | 90-34-6 | sc-483239 | 1 g | $360.00 | 1 | |
Primaquine is a cationic drug known to interact with organic cation transporters. It can enhance the functional activity of OCTN2 by being a substrate and promoting transport activity. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
Quinidine is a class I antiarrhythmic agent known to interact with organic cation transporters, potentially enhancing OCTN2 activity by acting as a substrate and promoting transport function. | ||||||
Procainamide hydrochloride | 614-39-1 | sc-202297 | 10 g | $53.00 | ||
Procainamide is a class Ia antiarrhythmic agent known to interact with organic cation transporters, potentially enhancing OCTN2 activity by acting as a substrate and promoting transport function. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
Furosemide is a loop diuretic known to interact with organic cation transporters. It can enhance the functional activity of OCTN2 by acting as a substrate and promoting transport activity. | ||||||