OC-STAMP Inhibitors
OC-STAMP inhibitors are a class of chemical compounds designed to target a specific molecular pathway in osteoclasts, which are specialized cells responsible for the resorption and remodeling of bone tissue. The name "OC-STAMP" stands for "Osteoclast Stimulatory Transmembrane Protein," which is a critical regulator of osteoclast fusion and function. Osteoclasts play a pivotal role in bone homeostasis by breaking down old or damaged bone tissue to make way for new bone formation. OC-STAMP is a transmembrane protein expressed on the surface of osteoclast precursors and is essential for the fusion of these cells into multinucleated osteoclasts, allowing them to become functional bone-resorbing units. Inhibiting OC-STAMP can modulate osteoclast formation and activity, making it a target for controlling bone metabolism.
The development of OC-STAMP inhibitors has gained attention in the field of bone research due to their potential to influence bone turnover. By selectively blocking the OC-STAMP pathway, these inhibitors may provide a means to regulate osteoclast differentiation and activity, which could have implications for conditions associated with excessive bone resorption, such as osteoporosis or certain bone metastases. Researchers are actively exploring various compounds and strategies to inhibit OC-STAMP, with the aim of better understanding its role in bone physiology and developing new tools for the management of bone-related disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can modulate the activity of a wide range of kinases potentially involved in the signaling pathways of the protein. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3K, which can affect downstream signaling pathways that the protein may be a part of. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibits MEK1/2, which could alter the MAPK/ERK pathway that might intersect with the protein's function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAP kinase inhibitor, potentially modifying the stress response pathway that could be linked to the protein's activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor that can indirectly affect the signaling pathways involving the protein. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, which could indirectly influence the protein's function if it's related to cell growth or autophagy. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Specifically inhibits MEK, which could affect the pathways the protein is involved in. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, altering the AP-1 transcription factor pathway that the protein may influence. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
A potent and selective inhibitor of Gs-alpha, possibly affecting the protein's role in GPCR signaling. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A Src family kinase inhibitor, potentially impacting the protein's signaling cascade. | ||||||