OATP-B Inhibitors
The chemical class known as OATP-B inhibitors comprises a group of compounds designed to modulate the activity of Organic Anion Transporting Polypeptide B (OATP-B), also referred to as OATP2B1. OATP-B is a membrane-bound transporter protein that facilitates the transmembrane uptake of a wide range of endogenous and exogenous compounds in various tissues, most notably in the liver. OATP-B inhibitors are synthesized with the aim of interfering with the natural function of this transporter by specifically targeting its molecular mechanisms. These inhibitors are developed through a combination of structural and functional studies of OATP-B, utilizing techniques such as computational modeling, high-throughput screening, and chemical synthesis.
The ultimate objective is to identify compounds that interact with OATP-B, thereby modulating its transport activity and potentially influencing the cellular uptake of diverse molecules. The exploration of OATP-B inhibitors contributes to a deeper understanding of the complex interplay between transporter proteins and the substances they transport, shedding light on the intricate processes involved in cellular uptake and distribution.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
An antibiotic known for its inhibitory effects on OATP-B, potentially leading to drug interactions by affecting the uptake of co-administered drugs. | ||||||
Cyclosporine | 79217-60-0 | sc-358111 sc-358111A | 100 mg 1 g | $191.00 $992.00 | 2 | |
A well-known immunosuppressive agent that has been shown to inhibit OATP-B, influencing the absorption and distribution of various drugs. | ||||||
Ritonavir | 155213-67-5 | sc-208310 | 10 mg | $122.00 | 7 | |
Ritonavir has been studied for its potential to inhibit OATP-B and alter drug pharmacokinetics. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin has been investigated for its inhibitory effects on OATP-B, which could impact the uptake of other concurrently administered drugs. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
An antibiotic that has been shown to inhibit OATP-B, potentially affecting the pharmacokinetics of co-administered drugs. | ||||||
Atazanavir | 198904-31-3 | sc-207305 | 5 mg | $286.00 | 7 | |
Atazanavir has been studied for its interactions with OATP-B, which might influence the absorption of certain drugs. | ||||||
PSC 833 | 121584-18-7 | sc-361298 sc-361298A sc-361298B sc-361298C sc-361298D | 1 mg 10 mg 50 mg 100 mg 1 g | $213.00 $724.00 $2522.00 $4253.00 $26884.00 | 12 | |
An experimental drug that has been explored for its potential as an OATP-B inhibitor to enhance the efficacy of anticancer agents. | ||||||
Tolvaptan | 150683-30-0 | sc-364638 sc-364638A | 10 mg 50 mg | $122.00 $612.00 | ||
Tolvaptan has been studied for its interactions with OATP-B, potentially affecting drug uptake and disposition. | ||||||
Pazopanib Hydrochloride | 635702-64-6 | sc-364564 sc-364564A | 10 mg 25 mg | $107.00 $230.00 | 1 | |
An anticancer drug that has been explored for its inhibitory effects on OATP-B transporters, which could impact drug absorption and distribution. | ||||||