OASL1 Activators
OASL1 Activators are a class of compounds that, through various mechanisms, enhance the functional activity of the OASL1 protein, which plays a crucial role in the innate immune response, especially in antiviral pathways. Resiquimod and Gardiquimod, both agonists of TLR7 and TLR8, initiate a signaling cascade that results in the upregulationof type I interferons, which are known to increase the expression and activity of OASL1. Similarly, Imiquimod, by activating TLR7, induces a pro-inflammatory and antiviral state that includes the upregulation of OASL1. Poly(I:C), a synthetic analog of dsRNA, activates TLR3 and RIG-I-like receptors, leading to the activation of IRF3 and subsequent production of type I interferons, further enhancing OASL1's role in antiviral defense.
Moreover, Piperlongumine acts to heighten the interferon response, indirectly leading to an increase in OASL1 activity. Fludarabine, a nucleotide analog, activates DNA damage pathways and, through the activation of p53, may also influence the interferon response, thus enhancing OASL1 activity. Anakinra, despite its primary role as an IL-1 receptor antagonist, may have secondary effects on the interferon signaling pathways, potentially upregulating OASL1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
Resiquimod is an agonist of Toll-like receptors 7 and 8 (TLR7/8). Activation of TLRs leads to downstream signaling through the MyD88-dependent pathway, which can enhance the production of type I interferons. OASL1 is an interferon-stimulated gene, and its activity is upregulated in response to type I interferon signaling. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Polyinosinic:polycytidylic acid is a synthetic analog of double-stranded RNA (dsRNA). It activates TLR3 and the retinoic acid-inducible gene I (RIG-I)-like receptors, which leads to interferon regulatory factor 3 (IRF3) activation and subsequent type I interferon production, promoting the activity of OASL1. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod is an immune response modifier that activates TLR7. This activation induces the production of pro-inflammatory cytokines and type I interferons, thereby enhancing the functional activity of OASL1 as part of the antiviral response. | ||||||
Gardiquimod | 1020412-43-4 | sc-221663 sc-221663A sc-221663B sc-221663C sc-221663D sc-221663E sc-221663F | 25 mg 50 mg 100 mg 250 mg 5 g 10 g 25 g | $157.00 $282.00 $516.00 $1177.00 $20138.00 $32779.00 $70753.00 | 1 | |
Gardiquimod is a selective TLR7 agonist. It triggers the TLR7 signaling cascade, leading to increased expression of interferon-stimulated genes, including OASL1, which is involved in the antiviral defense mechanism. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine increases the expression of genes involved in the antiviral response, including those stimulated by interferons. By enhancing the interferon response, it indirectly upregulates OASL1 activity. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $58.00 $204.00 | 15 | |
Fludarabine is a nucleotide analog that can activate DNA damage pathways, indirectly leading to the activation of p53. p53 has been implicated in the regulation of the interferon response, which could enhance the activity of OASL1. | ||||||
Anakinra | 143090-92-0 | sc-507486 | 10 mg | $811.00 | ||
Anakinra is an IL-1 receptor antagonist that can modulate the inflammatory response. By reducing IL-1 activity, it may indirectly affect interferon signaling, potentially increasing the activity of interferon-stimulated genes like OASL1. | ||||||