NYD-SP29 Inhibitors
The chemical class designated as NYD-SP29 Inhibitors consists of a range of compounds that indirectly influence the function of NYD-SP29, a protein vital to the assembly and operation of dynein arms in cilia and flagella. This class of inhibitors is distinguished by its indirect approach to modulation, targeting not the NYD-SP29 protein directly, but the broader cellular processes and signaling pathways where NYD-SP29 exerts its influence. The emphasis is on manipulating those cellular mechanisms that are intricately linked to the activity and role of NYD-SP29, thereby achieving an indirect effect on its function. These compounds are adept at affecting systems related to microtubule dynamics, signal transduction, and ciliary signaling, all of which are integral to NYD-SP29's role in ciliary and flagellar movement and assembly.
In this context, inhibitors that affect dynein activity play a significant role, given NYD-SP29's involvement in dynein arm assembly. By altering the functionality of dynein, these compounds can disrupt the proper operation of cilia and flagella, which depend on NYD-SP29's activity. Additionally, compounds that impact the stability and dynamics of microtubules are also crucial, as these structures are fundamental to the movement and assembly of cilia and flagella, where NYD-SP29 is operational. Furthermore, compounds that can alter actin dynamics are considered part of this class, considering the interconnected nature of actin and microtubule-based processes, which are essential for NYD-SP29's function in ciliary and flagellar dynamics. Compounds that modulate intracellular signaling pathways influencing ciliary beat frequency and pattern are also key, as they can indirectly modulate the role of NYD-SP29 in ciliary function. The unique characteristic of this class of inhibitors is their targeted approach to modifying specific cellular and molecular processes that, while not directly involving NYD-SP29, are critical to its expression and functional impact in ciliary and flagellar assembly and dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine disrupts microtubule polymerization. By altering microtubule dynamics, it could indirectly impact NYD-SP29's role in ciliary and flagellar movement. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine is another microtubule-targeting agent that can disrupt microtubule assembly. Its effects on microtubules could indirectly affect DNAI3 functions related to cilia. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent. Its impact on microtubules may indirectly affect NYD-SP29’s involvement in ciliary movement and assembly. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D inhibits actin polymerization. Although its primary target is actin, changes in actin dynamics can have secondary effects on microtubule-based processes, potentially affecting NYD-SP29. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can influence ciliary beat frequency and pattern. This might indirectly modulate NYD-SP29's role in ciliary function. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Blebbistatin inhibits myosin II. While it primarily affects actin-myosin interactions, changes in cellular contractility can indirectly influence ciliary functions involving NYD-SP29. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts Golgi apparatus function. Since ciliogenesis involves Golgi-derived vesicles, this might indirectly impact NYD-SP29’s role in cilia. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR signaling, which is involved in cell growth and autophagy. This might indirectly affect ciliary functions and NYD-SP29. | ||||||