NUDT8 Activators
NUDT8 play pivotal roles in various metabolic and regulatory pathways by facilitating the protein's enzymatic functions. S-Adenosylmethionine is known for its role in methylation reactions, where it donates a methyl group; this action can enhance the methylation-related enzymatic activity of NUDT8, effectively promoting its role in nucleotide metabolism. NADH, as a carrier of electrons, provides the necessary reducing equivalents for an array of biosynthetic reactions, which is essential for the redox regulation functions attributed to NUDT8. Additionally, ADP-ribose, by serving as a substrate, directly engages with NUDT8 in ADP-ribose/ATP exchange reactions that are critical for maintaining cellular energy balance. Nicotinamide mononucleotide, a precursor for NAD+ biosynthesis, supports NUDT8's involvement in energy metabolism by providing necessary substrates for enzymatic reactions.
Magnesium chloride supplies the Mg2+ ions, which are indispensable for the catalytic action of NUDT8, as these ions often stabilize nucleotide-binding sites and facilitate enzymatic processes. Glucose-6-phosphate, a key intermediate in glucose metabolism, is another activator that supports NUDT8's potential role in regulating energy utilization and production within cells. Coenzyme A contributes to NUDT8's activity in fatty acid metabolism and may enhance its role in modulating coenzyme A levels within the cell. Inositol hexakisphosphate, as a signaling molecule, can activate NUDT8 by influencing the enzyme's participation in nucleotide metabolism. Dithiothreitol ensures the structural stability of NUDT8 by maintaining the reduced state of cysteine residues, which is essential for its functional integrity. GTP, being a purine nucleotide, could act as a substrate for NUDT8, potentially enhancing its activity in nucleotide regulation. Thiamine pyrophosphate and Flavin adenine dinucleotide, as cofactors, activate NUDT8 by engaging in enzymatic reactions within the carbohydrate metabolism pathways and redox reactions, respectively, underpinning NUDT8's multifaceted role in cellular metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
S-Adenosylmethionine (SAM) activates NUDT8 by donating a methyl group in methylation reactions, which is a process NUDT8 is potentially involved in due to its relation to nucleotide metabolism and modification. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NADH provides reducing equivalents for biosynthetic reactions, thereby supporting the enzymatic activity of NUDT8 in redox homeostasis and energy metabolism. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
Nicotinamide mononucleotide (NMN) serves as a precursor for NAD+ biosynthesis, which is tightly linked with the enzymatic activity of NUDT8, thus promoting its function in energy metabolism. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium chloride provides Mg2+ ions necessary for the catalytic activity of NUDT8 as many nucleotide-processing enzymes require divalent cations for their activation and stability. | ||||||
D-Glucose 6-phosphate disodium salt | 3671-99-6 | sc-221488 sc-221488A sc-221488B | 10 mg 1 g 25 g | $39.00 $67.00 $1124.00 | 1 | |
Glucose-6-phosphate activates NUDT8 by participating in glucose metabolism pathways where NUDT8 is presumed to be active, thus facilitating the enzyme's role in cellular energy balance. | ||||||
Coenzyme A | 85-61-0 anhydrous | sc-211123 sc-211123A sc-211123B sc-211123C | 10 mg 25 mg 100 mg 250 mg | $83.00 $135.00 $418.00 $801.00 | 1 | |
Coenzyme A is involved in fatty acid metabolism and activates NUDT8 by participating in acyl group transfer reactions where NUDT8 could play a role in modulating coenzyme A levels. | ||||||
Phytic acid solution | 83-86-3 | sc-205806 sc-205806A | 100 ml 500 ml | $151.00 $515.00 | ||
Inositol hexakisphosphate activates NUDT8 by acting as a signaling molecule that may modulate the activity of enzymes involved in nucleotide metabolism, including NUDT8. | ||||||
Guanosine 5′-triphosphate trisodium salt | 36051-31-7 | sc-215111 sc-215111A | 10 mg 25 mg | $46.00 $71.00 | ||
GTP activates NUDT8 by serving as a potential substrate or cofactor, as NUDT8 is involved in the regulation and metabolism of nucleotides. | ||||||
Thiamine pyrophosphate | 154-87-0 | sc-215966 sc-215966A sc-215966B sc-215966C sc-215966D | 1 g 5 g 25 g 100 g 1 kg | $33.00 $97.00 $290.00 $1149.00 $6024.00 | 1 | |
Thiamine pyrophosphate (TPP) activates NUDT8 as a cofactor for enzymes that NUDT8 may interact with in the metabolism of sugars, thus influencing its activity. | ||||||