Date published: 2026-5-6

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NUDT6 Inhibitors

Chemical inhibitors of NUDT6 can exert their functional inhibitory effects through interference with various cellular signaling pathways in which NUDT6 is involved. Suramin, a growth factor receptor inhibitor, hampers the function of FGF receptors, which NUDT6 is associated with through its anti-sense RNA regulation of FGF-2. This disruption can lead to a decrease in FGF-2 signaling, thereby inhibiting the physiological functions of NUDT6. Similarly, PD173074, a selective FGFR inhibitor, directly targets FGFR, leading to a downstream reduction in FGF-2 mediated processes, which in turn inhibits NUDT6 activity. LY294002 and Wortmannin, both PI3K inhibitors, can halt the PI3K/AKT pathway, which is downstream of FGF-2 signaling. Since NUDT6 is potentially implicated in this pathway, such inhibition can suppress its function. Additionally, U0126 and PD0325901, as inhibitors of MEK1/2, disrupt the MAPK/ERK pathway, resulting in the inhibition of NUDT6 due to its putative involvement in this pathway. SP600125 and SB203580, which target JNK and p38 MAPK respectively, can also inhibit the MAPK pathway and therefore the function of NUDT6. Further, Dorsomorphin, by inhibiting BMP signaling, can indirectly hinder NUDT6 activity, presuming that NUDT6 acts within these pathways. Rapamycin, an mTOR inhibitor, can suppress cell growth and proliferation signals that are downstream of FGF-2, which NUDT6 may regulate, leading to its functional inhibition. The ROCK inhibitor Y-27632 can alter the actin cytoskeleton organization, a process that can be influenced by FGF-2 signaling. This alteration can restrict the cellular functions where NUDT6 is involved. ZM 447439, an Aurora kinase inhibitor, affects cell cycle and mitosis, which are cellular events where NUDT6 could play a role through the FGF-2 signaling pathway, leading to the inhibition of NUDT6..

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Suramin sodium

129-46-4sc-507209
sc-507209F
sc-507209A
sc-507209B
sc-507209C
sc-507209D
sc-507209E
50 mg
100 mg
250 mg
1 g
10 g
25 g
50 g
$152.00
$214.00
$728.00
$2601.00
$10965.00
$21838.00
$41096.00
5
(1)

Suramin is an inhibitor of various growth factors and their receptors. NUDT6 is an anti-sense RNA that may regulate FGF-2, hence Suramin inhibiting FGF receptors, can lead to the functional inhibition of NUDT6's associated pathways.

PD173074

219580-11-7sc-202610
sc-202610A
sc-202610B
1 mg
5 mg
50 mg
$47.00
$143.00
$680.00
16
(1)

PD173074 is a selective FGFR inhibitor. By inhibiting FGFR, which is associated with the pathways NUDT6 may regulate, PD173074 can lead to the functional inhibition of NUDT6.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a PI3K inhibitor, which can inhibit the PI3K/AKT pathway, downstream of FGF-2, potentially leading to the inhibition of NUDT6's function in this pathway.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U0126 is an inhibitor of MEK1/2, which are involved in the MAPK/ERK pathway, downstream of FGF-2. As NUDT6 may be involved in this pathway, its inhibition can lead to NUDT6 functional inhibition.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is an inhibitor of JNK, part of the MAPK pathway. Through inhibition of JNK, this chemical can lead to functional inhibition of NUDT6 in the MAPK pathway.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 inhibits p38 MAPK, which is part of the MAPK pathway. Inhibition of p38 MAPK can consequently inhibit NUDT6's function within this signaling pathway.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin is a PI3K inhibitor, like LY294002, and can inhibit the PI3K/AKT pathway, potentially leading to functional inhibition of NUDT6's role in this pathway.

BML-275

866405-64-3sc-200689
sc-200689A
5 mg
25 mg
$96.00
$355.00
69
(1)

Dorsomorphin is an inhibitor of BMP signaling and can inhibit ALK2, ALK3, and ALK6. As BMP signaling is part of the pathways NUDT6 may regulate, its inhibition could lead to the functional inhibition of NUDT6.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, which is involved in cell growth and proliferation downstream of FGF-2. Inhibition of mTOR can lead to functional inhibition of NUDT6 due to its potential regulation by FGF-2 signaling.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$186.00
$707.00
88
(1)

Y-27632 is a ROCK inhibitor, and by inhibiting ROCK, it can influence actin cytoskeleton organization. As the actin cytoskeleton can be influenced by FGF-2, this could lead to functional inhibition of NUDT6.