Suramin sodium CAS: 129-46-4
MF: C51H34N6O23S6•6Na
MW: 1429.17
A G protein uncoupler and inhibitor of PDGF, EGF, TGFb, SIRT1 and SIRT5.

Suramin sodium (CAS 129-46-4)

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同义词: Suramine sodium salt
应用; A G protein uncoupler and inhibitor of PDGF, EGF, TGFb, SIRT1 and SIRT5
CAS号码: 129-46-4
纯度: ≥98%
分子量: 1429.17
分子式: C51H34N6O23S66Na
* 参考分析证明 大量特定数据 (包括水 含量).
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Suramin Sodium uncouples G proteins from receptors by blocking their interaction with intracellular, P2X and P2Y, purinergic receptor domains. The compound also inhibits the cell surface binding of various growth factors including PDGF, FGF-2 (FGFb), FGF-1 (FGFa), EGF and TGF-β. It is a potent competitive inhibitor of reverse transcriptase and protects T lymphocytes against in vitro human immunodeficiency virus infection. Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and tumor cell metastasis. Inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 μM along with SIRT5 has also been observed. Suramin Sodium has been recorded to antagonize EDG-3 (S1P3) selectively. Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4, PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF.


参考文献

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3. Hosang, M. 1985. J. Cell. Biochem. 29: 265-273. PMID: 4077932
4. Betsholtz, C., et al. 1986. Proc. Natl. Acad. Sci. U.S.A. 83: 6440-6444. PMID: 3018732
5. Coffey, R.J., et al. 1987. J. Cell. Physiol. 132: 143-148. PMID: 3496343
6. Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50: 6490-6496. PMID: 2170005
7. Huang, R.R., et al. 1990. Mol. Pharmacol. 37: 304-310. PMID: 2154676
8. Nakajima, M., et al. 1991. J. Biol. Chem. 266: 9661-9666. PMID: 2033058
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物理状态 :
Solid
溶解度 :
Soluble in water (50 mg/mL), 95% ethanol, and DMSO (10 mM). Insoluble in benzene, ether, and chloroform.
保存 :
Store at room temperature
IC50 :
Trypanosoma brucei: IC50 = 43 nM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
QM7000000
PubChem CID :
8514
默克索引 :
14: 9006
MDL 号码 :
MFCD00210217
EC号码 :
204-949-3
SMILES :
CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

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引用1 - 66

PMID: # 27226534  Chen, L. et al. 2016. The Journal of biological chemistry.

PMID: # 26112648  Albulescu, IC. et al. 2015. Antiviral research. 121: 39-46.

PMID: # 25989529  Torres-Fuentes, JL. et al. 2015. Journal of cellular physiology. 230: 3068-75.

PMID: # 26187851  Li, S. et al. 2015. Journal of cell science. 128: 3317-29.

PMID: # 25822366  Chen, CW. et al. 2015. Nature medicine. 21: 335-43.

PMID: # 24829459  Calderon, MR. et al. 2014. Nucleic acids research. 42: 7012-27.

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