NR2E3 Activators
Chemical activators of NR2E3 can play a significant role in enhancing the protein's function within the cellular environment of retinal cells. For instance, 9-cis Retinoic acid serves as a ligand for retinoic acid receptors that can form heterodimers with NR2E3, directly enhancing its ability to regulate gene expression critical for retinal development and function. The integration of Docosahexaenoic acid (DHA) into photoreceptor membranes can improve the cellular milieu, which is conducive to the activity of NR2E3, a pivotal player in photoreceptor development and maintenance. Similarly, taurine, abundant in the retina, supports the health of photoreceptors, indirectly facilitating NR2E3's role in these cells. The presence of carotenoids such as Lutein and Zeaxanthin in the retina bolsters photoreceptor function and, by extension, may aid the functional activation of NR2E3. Astaxanthin's potent antioxidant capacity may also protect retinal cells, thus promoting the functional activation of NR2E3.
In addition to these, other compounds like Curcumin provide neuroprotective effects that can sustain the retinal cells' viability where NR2E3 is active, indirectly leading to its functional activation. Sulforaphane, through its induction of the Nrf2 pathway, contributes to cellular defense mechanisms, which could indirectly support the role of NR2E3 in the retina. Alpha-lipoic acid, known for maintaining the redox state in cells, could preserve the health of retinal cells, thereby indirectly supporting the functional activity of NR2E3. Quercetin, by sustaining retinal cell health, enhances the cellular context for NR2E3 activation. Lastly, Epigallocatechin gallate (EGCG), renowned for its neuroprotective properties, could support the health of retinal cells, thereby facilitating the activation of NR2E3 within its functional setting. Each of these chemicals contributes to the cellular environment that is critical for the functional activation of NR2E3, ensuring its role in retinal cell health and function is maintained.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
This retinoid is a ligand for retinoic acid receptors, which can heterodimerize with NR2E3, leading to its functional activation and subsequent regulation of gene expression related to retinal development and function. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA is an omega-3 fatty acid that can integrate into photoreceptor membranes, enhancing the cellular environment and potentially facilitating NR2E3's role in the development and maintenance of these cells. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $47.00 $100.00 | 1 | |
As an abundant amino acid in the retina, taurine may support photoreceptor health, thus indirectly facilitating the functional activity of NR2E3 in the maintenance of these cells. | ||||||
Xanthophyll | 127-40-2 | sc-220391 sc-220391A | 25 mg 100 mg | $566.00 $1163.00 | 2 | |
This carotenoid is known to accumulate in the retina and may support the functionality of photoreceptors and hence NR2E3 activity by maintaining an optimal retinal environment. | ||||||
Zeaxanthin | 144-68-3 | sc-205544 sc-205544A | 500 µg 1 mg | $265.00 $454.00 | 5 | |
Similar to lutein, zeaxanthin accumulates in the retina and can support photoreceptor function, potentially aiding in the functional activation of NR2E3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to provide neuroprotective effects in retinal cells, which may indirectly enhance the functional activity of NR2E3 through cellular stress response pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can exert neuroprotective effects, potentially supporting the cellular functions where NR2E3 is active, leading to its functional activation in maintaining retinal cell health. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which is involved in cellular defense mechanisms; this activation can indirectly facilitate the functional role of NR2E3 in retinal cells. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
This antioxidant can help maintain the redox state in retinal cells, indirectly supporting the functional activity of NR2E3 in these cells. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, has been shown to support the health of retinal cells, potentially enhancing the cellular context for NR2E3's functional activation. | ||||||