Notum Activators
Notum is a key player in the complex world of cellular signaling, acting as a carboxylesterase enzyme that regulates the Wnt signaling pathway. The Wnt signaling pathway is a network of proteins that relay signals from outside the cell to the interior, impacting numerous biological processes. Notum achieves its regulatory role by removing a palmitoleate moiety from Wnt proteins, thereby influencing their activity and interaction with receptors. This modulation of the Wnt pathway is instrumental in various developmental processes and biological phenomena. Moreover, imbalances or dysregulation in Notum's function are linked to various diseases, underscoring its critical role in maintaining cellular health and homeostasis.
In the realm of cellular biology and biochemistry, the regulation of proteins like Notum piques scientific interest. Certain chemical compounds, for instance, have been studied for their potential in inducing the expression of the Notum protein. These activators range from naturally occurring compounds in our diet to synthetic substances used in laboratory research. Some notable examples include retinoic acid, a vitamin A metabolite known for its role in cell differentiation, and dexamethasone, a synthetic glucocorticoid that interacts with cellular receptors. Natural compounds like genistein, a soy isoflavone, and curcumin, a component of turmeric, also show potential in this regard, likely due to their interaction with various cellular pathways. It's important to note that while these compounds have been studied for their influence on Notum expression, the exact mechanisms and consequences of such interactions are often complex, and further research is needed to fully understand their implications. This fascinating interplay between compounds and proteins like Notum continues to be a rich area of research, providing valuable insights into the intricate workings of cellular signaling and regulation.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, can induce the expression of Notum as part of its role in regulating cell differentiation and development. Its role in embryogenesis makes it a key player in the regulation of Notum. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
This synthetic glucocorticoid may stimulate Notum expression by binding to glucocorticoid receptors, which can subsequently interact with Notum gene promoter regions. It is often used in laboratory studies due to its potent anti-inflammatory and immunosuppressant properties. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a soy isoflavone, may induce Notum expression through its estrogenic activity and interaction with estrogen receptors, which can modulate Notum gene transcription. Its potential antioxidant and anti-inflammatory activities add to its complex interactions with cellular pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may upregulate Notum through its anti-inflammatory properties and ability to modulate various signaling pathways, including the Wnt pathway. It is a major component of turmeric. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might upregulate Notum expression as part of its role in modulating various signaling pathways, including the Wnt pathway. It is found in high concentrations in grapes and red wine, and is often studied for its potential health benefits. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic acid, a B-vitamin, may induce Notum expression as part of its role in DNA synthesis and methylation, processes that can affect gene expression. It is particularly important during periods of rapid cell division and growth such as during pregnancy. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, may stimulate Notum expression by inhibiting histone deacetylases, which can affect gene transcription. It is produced in the gut by bacterial fermentation of dietary fiber and plays a role in intestinal health. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane, a compound found in cruciferous vegetables, may upregulate Notum through its ability to modulate the Wnt signaling pathway. Its potential anticarcinogenic properties have been of interest in numerous research studies. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, may induce Notum expression through its antioxidant properties and ability to influence various signaling pathways. It is found in a wide variety of fruits and vegetables, and is known for its potential anti-inflammatory and antioxidant benefits. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate, a catechin from green tea, may stimulate Notum expression through its antioxidant properties and potential modulation of the Wnt signaling pathway. It is the most abundant catechin in green tea, and has been extensively studied for its potential health effects. | ||||||