The chemical class identified as NOMO2 Inhibitors represents a category of compounds intricately designed to selectively target NOMO2, a molecular entity with emerging significance in cellular processes and RNA regulation. NOMO2, or NODAL Modulator 2, belongs to the NOMO family and has been recognized for its involvement in modulating NODAL signaling, which is crucial in embryonic development and cellular differentiation. While the specific functions and regulatory mechanisms of NOMO2 are areas of active research, its connection to NODAL signaling hints at its potential role in orchestrating intricate molecular events during developmental processes. Inhibitors within the NOMO2 Inhibitors class are meticulously engineered molecules with the primary goal of modulating the activity or function of NOMO2, thereby inducing an inhibitory effect. Researchers in this field employ a multidisciplinary approach, integrating insights from molecular biology, biochemistry, and structural biology to unravel the complex molecular interactions between the inhibitors and the target NOMO2.
Structurally, NOMO2 Inhibitors are characterized by specific molecular features tailored to facilitate selective binding to NOMO2. This selectivity is crucial to minimize unintended effects on other members of the NOMO family or cellular components, ensuring a focused impact on the intended molecular target. The development of inhibitors within this chemical class involves a comprehensive exploration of structure-activity relationships, optimization of pharmacokinetic properties, and a deep understanding of the molecular mechanisms associated with NOMO2. As researchers delve deeper into the functional aspects of NOMO2 Inhibitors, the knowledge generated contributes not only to deciphering the specific roles of NODAL Modulator 2 but also to advancing our broader comprehension of embryonic development, signaling pathways, and the intricate molecular events governing cellular differentiation. The exploration of NOMO2 Inhibitors stands as a significant avenue for expanding fundamental knowledge in developmental biology and molecular pharmacology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 selectively inhibits the TGF-β type I receptor ALK5, which could downregulate the TGF-β pathway and affect NOMO2 expression. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
LY364947 is a potent inhibitor of ALK5, and by inhibiting this receptor, it may impact the expression of related proteins like NOMO2. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
This compound inhibits ALK4, ALK5, and ALK7, which are involved in TGF-β signaling, potentially reducing NOMO2 expression. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
LY2157299 blocks TGF-β receptor I, potentially affecting downstream proteins such as NOMO2 in the signaling pathway. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $77.00 $153.00 $219.00 $663.00 $1248.00 $4382.00 $7850.00 | 8 | |
RepSox is an ALK5 inhibitor that may interfere with TGF-β signaling and consequently NOMO2 expression. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
While not a direct inhibitor, paclitaxel affects microtubule dynamics and can alter TGF-β signaling and potentially NOMO2 expression. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $102.00 $416.00 | 6 | |
Pirfenidone has been shown to downregulate TGF-β, which could lead to a decrease in NOMO2 expression. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
Tranilast modulates the release of TGF-β and may influence the expression of proteins within its signaling pathway, including NOMO2. | ||||||
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
Halofuginone inhibits TGF-β type II receptor and Smad3 phosphorylation, possibly affecting NOMO2 expression. | ||||||
LY2109761 | 700874-71-1 | sc-396262 sc-396262A | 1 mg 5 mg | $89.00 $275.00 | 9 | |
This compound is a TGF-β receptor I/II dual inhibitor, which may lead to changes in the levels of NOMO2 expression. | ||||||