Date published: 2026-2-14

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NOMO2 Inhibitors

The chemical class identified as NOMO2 Inhibitors represents a category of compounds intricately designed to selectively target NOMO2, a molecular entity with emerging significance in cellular processes and RNA regulation. NOMO2, or NODAL Modulator 2, belongs to the NOMO family and has been recognized for its involvement in modulating NODAL signaling, which is crucial in embryonic development and cellular differentiation. While the specific functions and regulatory mechanisms of NOMO2 are areas of active research, its connection to NODAL signaling hints at its potential role in orchestrating intricate molecular events during developmental processes. Inhibitors within the NOMO2 Inhibitors class are meticulously engineered molecules with the primary goal of modulating the activity or function of NOMO2, thereby inducing an inhibitory effect. Researchers in this field employ a multidisciplinary approach, integrating insights from molecular biology, biochemistry, and structural biology to unravel the complex molecular interactions between the inhibitors and the target NOMO2.

Structurally, NOMO2 Inhibitors are characterized by specific molecular features tailored to facilitate selective binding to NOMO2. This selectivity is crucial to minimize unintended effects on other members of the NOMO family or cellular components, ensuring a focused impact on the intended molecular target. The development of inhibitors within this chemical class involves a comprehensive exploration of structure-activity relationships, optimization of pharmacokinetic properties, and a deep understanding of the molecular mechanisms associated with NOMO2. As researchers delve deeper into the functional aspects of NOMO2 Inhibitors, the knowledge generated contributes not only to deciphering the specific roles of NODAL Modulator 2 but also to advancing our broader comprehension of embryonic development, signaling pathways, and the intricate molecular events governing cellular differentiation. The exploration of NOMO2 Inhibitors stands as a significant avenue for expanding fundamental knowledge in developmental biology and molecular pharmacology.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$82.00
$216.00
$416.00
48
(1)

SB-431542 selectively inhibits the TGF-β type I receptor ALK5, which could downregulate the TGF-β pathway and affect NOMO2 expression.

LY 364947

396129-53-6sc-203122
sc-203122A
5 mg
10 mg
$107.00
$156.00
4
(1)

LY364947 is a potent inhibitor of ALK5, and by inhibiting this receptor, it may impact the expression of related proteins like NOMO2.

A 83-01

909910-43-6sc-203791
sc-203791A
10 mg
50 mg
$202.00
$811.00
16
(1)

This compound inhibits ALK4, ALK5, and ALK7, which are involved in TGF-β signaling, potentially reducing NOMO2 expression.

LY2157299

700874-72-2sc-391123
sc-391123A
5 mg
10 mg
$213.00
$359.00
3
(1)

LY2157299 blocks TGF-β receptor I, potentially affecting downstream proteins such as NOMO2 in the signaling pathway.

ALK5 Inhibitor II

446859-33-2sc-221234
sc-221234A
sc-221234B
sc-221234C
sc-221234D
sc-221234E
sc-221234F
1 mg
5 mg
10 mg
50 mg
100 mg
500 mg
1 g
$77.00
$153.00
$219.00
$663.00
$1248.00
$4382.00
$7850.00
8
(1)

RepSox is an ALK5 inhibitor that may interfere with TGF-β signaling and consequently NOMO2 expression.

Taxol

33069-62-4sc-201439D
sc-201439
sc-201439A
sc-201439E
sc-201439B
sc-201439C
1 mg
5 mg
25 mg
100 mg
250 mg
1 g
$41.00
$74.00
$221.00
$247.00
$738.00
$1220.00
39
(2)

While not a direct inhibitor, paclitaxel affects microtubule dynamics and can alter TGF-β signaling and potentially NOMO2 expression.

Pirfenidone

53179-13-8sc-203663
sc-203663A
10 mg
50 mg
$102.00
$416.00
6
(1)

Pirfenidone has been shown to downregulate TGF-β, which could lead to a decrease in NOMO2 expression.

Tranilast

53902-12-8sc-200389
sc-200389A
sc-200389B
sc-200389C
10 mg
50 mg
1 g
5 g
$31.00
$103.00
$283.00
$978.00
2
(1)

Tranilast modulates the release of TGF-β and may influence the expression of proteins within its signaling pathway, including NOMO2.

Halofuginone

55837-20-2sc-507290
100 mg
$1775.00
(0)

Halofuginone inhibits TGF-β type II receptor and Smad3 phosphorylation, possibly affecting NOMO2 expression.

LY2109761

700874-71-1sc-396262
sc-396262A
1 mg
5 mg
$89.00
$275.00
9
(1)

This compound is a TGF-β receptor I/II dual inhibitor, which may lead to changes in the levels of NOMO2 expression.