Date published: 2026-3-3

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NK-3R Activators

The chemical class designated as NK-3R Activators primarily comprises direct agonists, such as Senktide and [MePhe7]NKB(4-10), and indirect activators, such as Talnetant and SB 222200. The direct agonists of this class interact with NK-3R, triggering depolarization and excitatory responses. These agonists have a high affinity for NK-3R, ensuring a rapid and specific response upon interaction. The indirect activators, primarily antagonists, operate via a different mechanism. Although they initially serve as inhibitors to NK-3R, they can contribute to the protein's activation through negative feedback mechanisms, causing upregulation of the receptors or increased sensitivity. This class of compounds thus showcases a variety of mechanisms through which NK-3R can be regulated, contributing to the intricate balance of cellular signaling pathways.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Neurokinin B

86933-75-7sc-3139
1 mg
$97.00
1
(0)

Neurokinin B acts as a selective agonist for the neurokinin-3 receptor (NK-3R), facilitating intricate molecular interactions that modulate intracellular signaling cascades. Its unique peptide sequence enables robust receptor binding, promoting conformational changes that amplify downstream signaling. This activation influences various cellular processes, showcasing the dynamic role of neurokinins in regulating physiological functions and the intricate balance of neuropeptide interactions within biological systems.

Senktide

106128-89-6sc-201174
sc-201174A
1 mg
5 mg
$138.00
$548.00
1
(0)

Senktide is a potent NK-3R agonist characterized by its ability to induce specific conformational shifts in the neurokinin-3 receptor. This compound engages in selective binding, triggering a cascade of intracellular events that enhance signaling pathways. Its unique structural features allow for high affinity and specificity, leading to distinct receptor activation profiles. The kinetics of Senktide's interaction with NK-3R highlight its role in modulating neuropeptide dynamics and cellular responses.

CI 1020

162256-50-0sc-204687
sc-204687A
10 mg
50 mg
$175.00
$793.00
(0)

CI 1020 is a selective NK3 receptor antagonist, which could indirectly facilitate NK-3R activation through a negative feedback response.

SB 218795

174635-53-1sc-224280
sc-224280A
10 mg
50 mg
$193.00
$859.00
(0)

SB 218795 is a potent NK3 receptor antagonist. However, it can indirectly facilitate the activation of NK-3R through a negative feedback mechanism.