Molecular structure of CI 1020, CAS Number: 162256-50-0
CI 1020 (CAS 162256-50-0)
Alternate Names:
PD156707
Application:
CI 1020 is a highly selective non-peptide ETAR antagonist
CAS Number:
162256-50-0
Molecular Weight:
506.5
Molecular Formula:
C28H26O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Highly selective, orally active, non-peptide endothelin-A receptor (ETA) antagonist (IC50 values are 0.3 and 480 nM for ETA and ETB receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.
CI 1020 (CAS 162256-50-0) References
- Coronary arteriopathy in monkeys following administration of CI-1020, an endothelin A receptor antagonist. | Albassam, MA., et al. 1999. Toxicol Pathol. 27: 156-64. PMID: 10207979
- The effect of the endothelin ET(A) receptor antagonist CI-1020 on hypoxic pulmonary vasoconstriction. | Jones, RD., et al. 1999. Eur J Pharmacol. 374: 367-75. PMID: 10422781
- Studies on coronary arteriopathy in dogs following administration of CI-1020, an endothelin A receptor antagonist. | Albassam, MA., et al. 2001. Toxicol Pathol. 29: 277-84. PMID: 11442013
- The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in the perinatal lamb. | Coe, Y., et al. 2002. J Pharmacol Exp Ther. 302: 672-80. PMID: 12130731
- ETA receptor antagonists inhibit intimal smooth muscle cell proliferation in human vessels. | Maguire, JJ., et al. 2002. Clin Sci (Lond). 103 Suppl 48: 184S-188S. PMID: 12193082
- Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020. | Yokoyama, Y., et al. 2014. Biol Pharm Bull. 37: 461-5. PMID: 24583865
- Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists. | Doherty, AM., et al. 1995. J Med Chem. 38: 1259-63. PMID: 7731010
- Efficacy of CI-1020, an endothelin-A receptor antagonist, in hypoxic pulmonary hypertension. | Haleen, S., et al. 1998. J Cardiovasc Pharmacol. 31 Suppl 1: S331-5. PMID: 9595473
- The effect of the ETA receptor antagonist (CI-1020) in rats with established hypoxic pulmonary hypertension. | Sheedy, W., et al. 1998. Pulm Pharmacol Ther. 11: 173-6. PMID: 9918751
- The ETA antagonist CI-1020 inhibits hypoxic pulmonary vasoconstriction in small isolated rat pulmonary arteries. | Jones, RD. and Morice, AH. 1998. Pulm Pharmacol Ther. 11: 177-81. PMID: 9918752
Inhibitor of:
ETAR.Activator of:
NK-3R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CI 1020, 10 mg | sc-204687 | 10 mg | $175.00 | |||
| US: Only available in the US | ||||||
CI 1020, 50 mg | sc-204687A | 50 mg | $793.00 | |||
| US: Only available in the US | ||||||