Nim1 Inhibitors
Chemical inhibitors of Nim1 kinase act by competing with ATP for the binding to the catalytic kinase domain of Nim1, thereby impeding its phosphorylation activity. Staurosporine, a well-known protein kinase inhibitor, can inhibit Nim1 by directly competing with ATP for binding to the kinase's active site. This competition prevents the necessary phosphorylation reactions that Nim1 typically carries out. Similarly, 5-Iodotubercidin, an adenosine analog, binds to Nim1's ATP-binding pocket, thus forestalling ATP from engaging with the kinase and inhibiting its activity. Indirubin-3'-monoxime, another compound that targets kinases, obstructs Nim1's ATP pocket, which results in the inhibition of the kinase's ability to phosphorylate its substrates.
Further inhibition is achieved by H-89, which, although primarily a protein kinase A inhibitor, also can bind to Nim1, leading to the prevention of substrate phosphorylation. 6-DMAP, a kinase inhibitor, inhibits Nim1 by taking over the ATP-binding site, thereby blocking the kinase's phosphorylation activity. Compounds such as Olomoucine and Roscovitine, both of which are purine derivatives, inhibit Nim1 by competing with ATP at the ATP-binding site. Purvalanol A also engages in a similar mechanism of action by binding to the ATP-binding site, thus hindering the kinase's function. AZD5438 inhibits Nim1 in a comparable fashion, by binding to the ATP-binding pocket, which precludes the phosphorylation of Nim1's substrates. Alsterpaullone and CGP74514A, both potent inhibitors of cyclin-dependent kinases, exert their inhibitory effect on Nim1 by competing with ATP for binding to the kinase's ATP pocket. Lastly, Milciclib can inhibit Nim1 kinase by interfering with the kinase's ATP utilization at the ATP-binding site, which leads to the inhibition of Nim1's phosphorylation activity. Each of these inhibitors employs a mechanism that involves the occupation of the ATP-binding site of Nim1, ultimately disrupting its kinase activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent protein kinase inhibitor that can inhibit Nim1 kinase activity by competing with ATP for binding to the catalytic kinase domain of Nim1, thereby blocking its phosphorylation activity and substrate interactions. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $150.00 $455.00 | 20 | |
5-Iodotubercidin is an adenosine analog that inhibits various kinases, including Nim1. It can inhibit Nim1 by mimicking ATP and binding to its ATP-binding pocket, preventing ATP from binding and thus inhibiting its kinase activity. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $77.00 $315.00 $658.00 | 1 | |
Indirubin-3'-monoxime is known to inhibit cyclin-dependent kinases, and it can inhibit Nim1 by binding to its ATP pocket, obstructing the kinase's ability to phosphorylate its substrates. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
6-Dimethylaminopurine (6-DMAP) is a kinase inhibitor that can inhibit Nim1 by occupying the ATP-binding site, thereby preventing ATP from engaging with the kinase and inhibiting its phosphorylation activity. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is a purine derivative that inhibits cyclin-dependent kinases and can inhibit Nim1 by competing with ATP for binding to the ATP-binding site, thus inhibiting the kinase's activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a potent inhibitor of cyclin-dependent kinases and can inhibit Nim1 by binding to the ATP pocket, hindering the kinase's ability to phosphorylate its substrates, leading to inhibition of its kinase activity. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a cyclin-dependent kinase inhibitor that can inhibit Nim1 by binding to the ATP-binding site of the kinase, thus preventing ATP from binding and inhibiting kinase activity. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
AZD5438 inhibits cyclin-dependent kinases and can inhibit Nim1 by binding to its ATP-binding pocket, which prevents the kinase from phosphorylating its substrates and thus inhibits its activity. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a potent inhibitor of cyclin-dependent kinases, which can inhibit Nim1 by competing with ATP for binding to the kinase's ATP pocket, leading to inhibition of its kinase activity. | ||||||
PHA-848125 | 802539-81-7 | sc-364581 sc-364581A | 5 mg 10 mg | $304.00 $555.00 | ||
Milciclib is a cyclin-dependent kinase inhibitor that can inhibit Nim1 by binding to the ATP-binding site, interfering with the kinase's ATP utilization and thus inhibiting its phosphorylation activity. | ||||||