NgBR Activators
NgBR activators, or Nogo-B receptor activators, belong to a unique chemical class of compounds that specifically target the NgBR (Nogo-B receptor) protein, a cell surface receptor. NgBR is a transmembrane protein known for its essential role in various cellular processes, including the regulation of angiogenesis, a process crucial for the formation of new blood vessels. NgBR activators are designed to modulate the activity of NgBR, leading to downstream effects on cellular functions without directly interfering. These compounds are carefully crafted to interact with NgBR, often through small molecules or peptide-based approaches, and they have gained considerable attention in the field of basic research and molecular biology due to elucidate the intricate mechanisms of NgBR-related signaling pathways.
The discovery and development of NgBR activators have opened up exciting avenues for investigating the physiological and pathological roles of NgBR. Researchers use these compounds as valuable tools to manipulate NgBR activity, thus enabling the exploration of its impact on angiogenesis, lipid metabolism, and cellular signaling pathways. NgBR activators are invaluable for dissecting the intricate web of molecular interactions associated with NgBR, shedding light on its involvement in cellular homeostasis and disease states. These compounds hold immense promise for advancing our understanding of NgBR biology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II is a peptide hormone that can indirectly activate NgBR by promoting vasoconstriction and increasing blood pressure. Elevated levels of angiotensin II can lead to endothelial cell activation, potentially affecting NgBR signaling in vascular development. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that can activate NgBR through its role in regulating endothelial cell behavior and angiogenesis. S1P receptors on endothelial cells can trigger downstream signaling pathways that intersect with NgBR-related processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid and its derivatives may activate NgBR indirectly by modulating gene expression and cell differentiation. They can influence angiogenesis-related processes that intersect with NgBR signaling pathways. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ and its precursors can influence NgBR activity indirectly by impacting cellular metabolism and energy production. Changes in NAD+ levels may affect endothelial cell function and angiogenesis, potentially modulating NgBR. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin can activate NgBR by interacting with growth factors and cytokines involved in angiogenesis. It may enhance the bioavailability of these factors, indirectly influencing NgBR-mediated processes. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin can activate NgBR by triggering signaling cascades in endothelial cells. It can lead to endothelial cell activation and angiogenesis, potentially impacting NgBR-related pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandins, including PGE2, can activate NgBR through their role in regulating vascular tone and endothelial cell behavior. They may influence NgBR-mediated processes in the context of inflammation and angiogenesis. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT inhibits the Notch signaling pathway, which can indirectly activate NgBR by altering endothelial cell fate and angiogenesis. Inhibition of Notch can promote pro-angiogenic processes related to NgBR activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can activate NgBR by activating the PI3K/Akt pathway in endothelial cells. This pathway plays a role in cell survival and angiogenesis, potentially influencing NgBR-related processes. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
CoCl2 can activate NgBR by inducing hypoxia-like conditions, which can trigger angiogenesis-related pathways. It may stimulate NgBR-mediated responses in cells exposed to hypoxia-mimicking conditions. | ||||||