Date published: 2025-10-7

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NF-L Antibodies

Santa Cruz Biotechnology offers a broad range of NF-L monoclonal antibodies for studying neurofilament light chain (NF-L). NF-L Antibodies are available for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). NF-L is a critical component of the neuronal cytoskeleton, playing a vital role in maintaining neuronal structure and function. Expression levels of NF-L are often associated with neurodegenerative diseases, making it a significant biomarker for conditions such as multiple sclerosis and amyotrophic lateral sclerosis. Understanding NF-L dynamics can provide insights into neuronal health and disease progression. Researchers can utilize NF-L monoclonal antibodies to investigate structural changes in neurons during development and disease states. Advanced imaging techniques combined with NF-L monoclonal antibodies enable detailed visualization of neuronal architecture and cytoskeletal organization. Monitoring NF-L levels helps track disease progression and evaluate potential therapeutic interventions. Santa Cruz Biotechnology monoclonal antibodies for NF-L support researchers worldwide in advancing neurodegenerative disease research and potential therapeutic developments.

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NF-L Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

NF-L Antibody (8A1)

sc-20012mouse IgG1 κ(h)WB, IP, IF, IHC(P)m, r, h
27
(17)

NF-L Antibody (3F285)

sc-71678mouse IgG1 κraised against neurofilament purified from human brainWB, IP, IFm, r, h
5
(4)

NF-L Antibody (F-12)

sc-390732mouse IgG1 κ6-25 (h)WB, IP, IF, ELISAm, r, h
1
(1)

NF-L Antibody (NR4)

sc-58560mouse IgG1 κ(porcine)IFm, r, h
2
(1)

NF-L CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

NF-L CRISPR/Cas9 KO Plasmid (h)

sc-402254hGene KnockoutGFP0
(0)

NF-L HDR Plasmid (h)

sc-402254-HDRhHomology Directed RepairPuromycin0
(0)

NF-L Double Nickase Plasmid (h)

sc-402254-NIChGene KnockoutPuromycin0
(0)

NF-L Double Nickase Plasmid (h2)

sc-402254-NIC-2hGene KnockoutPuromycin0
(0)

NF-L CRISPR/Cas9 KO Plasmid (m)

sc-421882mGene KnockoutGFP0
(1)

NF-L CRISPR/Cas9 KO Plasmid (m2)

sc-421882-KO-2m2Gene KnockoutGFP0
(1)

NF-L HDR Plasmid (m2)

sc-421882-HDR-2m2Homology Directed RepairPuromycin0
(1)

NF-L Double Nickase Plasmid (m)

sc-421882-NICmGene KnockoutPuromycin0
(1)

NF-L Double Nickase Plasmid (m2)

sc-421882-NIC-2mGene KnockoutPuromycin0
(1)

NF-L CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

NF-L CRISPR Activation Plasmid (h)

sc-402254-ACThGene ActivationPuro, Blast, Hygro0
(0)

NF-L CRISPR Activation Plasmid (h2)

sc-402254-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

NF-L Lentiviral Activation Particles (h)

sc-402254-LAChGene ActivationPuro, Blast, Hygro0
(0)

NF-L Lentiviral Activation Particles (h2)

sc-402254-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

NF-L CRISPR Activation Plasmid (m)

sc-421882-ACTmGene ActivationPuro, Blast, Hygro0
(1)

NF-L CRISPR Activation Plasmid (m2)

sc-421882-ACT-2mGene ActivationPuro, Blast, Hygro0
(1)

NF-L Lentiviral Activation Particles (m)

sc-421882-LACmGene ActivationPuro, Blast, Hygro0
(1)

NF-L Lentiviral Activation Particles (m2)

sc-421882-LAC-2mGene ActivationPuro, Blast, Hygro0
(1)

NF-L siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

NF-L siRNA (h)

sc-36048hGene SilencingN/A
1
(0)

NF-L shRNA Plasmid (h)

sc-36048-SHhGene SilencingPuromycin
1
(0)

NF-L shRNA (h) Lentiviral Particles

sc-36048-VhGene SilencingPuromycin
1
(0)

NF-L siRNA (m)

sc-36049mGene SilencingN/A0
(0)

NF-L shRNA Plasmid (m)

sc-36049-SHmGene SilencingPuromycin0
(0)

NF-L shRNA (m) Lentiviral Particles

sc-36049-VmGene SilencingPuromycin0
(0)