NF-L Inhibitors
Neurofilament light chain (NF-L) is a pivotal component of the neurofilament triplet proteins, which are integral to the structure of neurons, specifically within the axonal cytoskeleton. NF-L plays a critical role in maintaining neuronal caliber and axonal integrity, thereby facilitating efficient axonal transport and signal transmission across neurons. The protein's structure and function are essential for the proper development and functioning of the nervous system, contributing to the stability and flexibility of axons, which is crucial for sustaining the high-speed conduction of nerve impulses. NF-L's assembly into intermediate filaments, alongside the medium (NF-M) and heavy (NF-H) neurofilament subunits, establishes the structural scaffold that supports neuronal architecture and is indispensable for neurophysiological processes.
The inhibition of NF-L involves mechanisms that disrupt its expression, assembly, or function within neurons, leading to alterations in the cytoskeletal organization and, consequently, neuronal integrity. Such inhibition can occur at the gene expression level, where factors that regulate NF-L mRNA transcription or stability are altered, thereby reducing the synthesis of NF-L protein. Additionally, post-translational modifications of NF-L, such as phosphorylation, acetylation, or ubiquitination, can modulate its assembly with other neurofilament subunits or its interaction with other cytoskeletal components, impacting the stability and function of the neurofilament network. Another mechanism of NF-L inhibition includes the interaction with cytoskeletal disruptors that interfere with the normal assembly process of NF-L into intermediate filaments, thereby compromising the structural integrity of axons. These inhibitory processes can lead to a cascade of events that affect axonal transport, nerve impulse conduction, and ultimately neuronal communication and health.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol is a microtubule stabilizer that binds to the β-subunit of tubulin in the microtubules. This binding prevents the depolymerization of microtubules, leading to the inhibition of NF-L by disrupting the microtubule dynamics required for its function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is an anti-neoplastic agent that binds to β-tubulin and inhibits microtubule polymerization. This interaction disrupts the microtubule dynamics, which can lead to the inhibition of NF-L. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules and affecting the microtubule dynamics. This action can inhibit the function of NF-L which requires proper microtubule assembly for its function. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $109.00 $412.00 $561.00 $2244.00 | 9 | |
Vinblastine is a vinca alkaloid that inhibits microtubule formation by binding to tubulin dimers. This inhibition can disrupt microtubule dynamics, leading to the indirect inhibition of NF-L. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
Docetaxel is a semi-synthetic analogue of paclitaxel and acts as a microtubule stabilizer. It binds to the β-subunit of tubulin in the microtubules, preventing their depolymerization. This action disrupts microtubule dynamics, which can inhibit the function of NF-L. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin is a synthetic analogue of halichondrin B and acts as a microtubule dynamics inhibitor. It binds to the plus ends of microtubules, inhibiting their growth. This disruption in microtubule dynamics can lead to the inhibition of NF-L. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole is a broad-spectrum antiparasitic agent in research that also inhibits tubulin polymerization. This inhibition disrupts the microtubule dynamics, which can inhibit the function of NF-L. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin is an antifungal agent in research that disrupts microtubule function by binding to polymerized microtubules. This action can inhibit the function of NF-L. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole is a broad-spectrum antiparasitic agent in research that inhibits tubulin polymerization, disrupting the microtubule dynamics. This disruption can inhibit the function of NF-L. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole is a fungicide and parasiticide that also inhibits tubulin polymerization. By disrupting microtubule dynamics, it can inhibit the function of NF-L. | ||||||