NF-1C Activators
NF-1C activators are a chemical class that primarily focuses on the modulation of a specific type of nuclear factor, known as NF-1C, which is a variant within the nuclear factor one (NF-1) family of transcription factors. These nuclear factors are proteins that bind to specific DNA sequences, thereby playing a pivotal role in the regulation of gene expression. NF-1C activators influence the activity of NF-1C, altering its capacity to interact with DNA within the cellular nucleus. The activation of NF-1C can lead to changes in the transcriptional activity of a variety of genes, which can have multiple downstream effects within cells. The specificity of these activators is a critical aspect of their function, as they are designed to target NF-1C without affecting other members of the NF-1 family or other transcription factors, ensuring a more selective mode of action.
The design and development of NF-1C activators are rooted in an intricate understanding of the structure and function of the NF-1C protein. This involves detailed knowledge of the protein's DNA-binding domain, which recognizes specific sequences in the genome, and its transactivation domain, which recruits other components of the transcriptional machinery. The exact mechanism by which NF-1C activators enhance the activity of NF-1C involves either direct binding to the protein, thereby stabilizing its active form, or interacting with other regulatory molecules that modulate NF-1C's function
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A activates NF-1C by inhibiting histone deacetylases. HDAC inhibition promotes NF-1C transcription, leading to increased expression and activation. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide activates NF-1C by inhibiting Wnt/β-catenin signaling. Wnt/β-catenin inhibition prevents NF-1C degradation, enhancing its stability and promoting activation. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide activates NF-1C by inhibiting NF-κB. NF-κB inhibition enhances NF-1C transcription, leading to increased expression and activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates NF-1C by inhibiting the NF-κB pathway. NF-κB inhibition enhances NF-1C transcription, leading to increased expression and activation. | ||||||
NSC-207895 | 58131-57-0 | sc-364550 sc-364550A | 5 mg 10 mg | $354.00 $666.00 | ||
NSC 207895 activates NF-1C by inhibiting Hsp90. Hsp90 inhibition prevents NF-1C degradation, leading to its stabilization and activation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine activates NF-1C through cyclin-dependent kinase inhibition. CDK inhibition enhances NF-1C transcription, leading to increased expression and activation. | ||||||