The category of Neuron navigator 2 Inhibitors encapsulates compounds that, although not necessarily directly intervening with NAV2, have the capacity to impinge on the broader processes or signaling conduits that NAV2 is implicated in. Being a central player in axonal guidance and neuronal development, NAV2's role in the regulation of the cytoskeleton is crucial. The compounds described predominantly target cellular machinery responsible for the dynamic regulation of the cytoskeleton, particularly the actin and microtubule networks.
Nocodazole, Taxol, and Colchicine, for instance, are renowned modulators of microtubule dynamics. By either stabilizing or destabilizing the microtubules, these agents can perturb the precise axonal guidance and growth processes where NAV2 is engaged. On the flip side, Cytochalasin D, Latrunculin A, Jasplakinolide, and Swinholide A are archetypal actin-targeting agents. They either inhibit actin polymerization, sequester actin monomers, or stabilize actin filaments, thus impacting the roles of NAV2 in actin-based cellular processes. Myosin modulators such as Blebbistatin and ML-7, along with ROCK inhibitors like Y-27632 and H-1152, underscore the intricate interplay between actin and myosin in cellular dynamics, in which NAV2 is presumably engaged. Collectively, these agents paint a picture of the wide-ranging cellular machinery, shedding light on points of intervention to modulate NAV2-associated processes in neuronal contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, which can affect NAV2-mediated axonal guidance. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits actin polymerization, impacting processes where NAV2 might be involved. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and can influence NAV2-related axonal outgrowth. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A sequesters actin monomers, affecting actin dynamics and potentially NAV2 function. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments, which can impact NAV2-mediated neuronal processes. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin inhibits myosin II, altering acto-myosin interactions and possibly affecting NAV2 roles. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and disrupts microtubule assembly, influencing NAV2-related pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor, and can influence pathways where NAV2 plays a role in cytoskeletal regulation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 inhibits myosin light chain kinase, affecting acto-myosin dynamics and potentially NAV2 function. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H-1152 is a potent ROCK inhibitor which can modulate cytoskeletal dynamics linked to NAV2. | ||||||