neuroligin 1 Activators
Neuroligin 1 activators belong to a class of chemical compounds that modulate the function of neuroligin 1, a postsynaptic cell adhesion molecule found in neurons. Neuroligin 1 is a key player in the formation and maintenance of synapses, the junctions through which neurons communicate with each other. Synapses are crucial for various neuronal functions and play a significant role in the proper functioning of the nervous system. Neuroligin 1, along with its counterpart neurexin (typically present on the presynaptic side), ensures the precision of synaptic connections, helping in the alignment of pre- and postsynaptic machinery. By influencing neuroligin 1's activity, these activators can impact synaptic structure and function, thus playing a role in modulating neural communication.
The mechanism by which neuroligin 1 activators operate typically involves increasing the binding affinity between neuroligin 1 and neurexin or amplifying the functional effect of neuroligin 1 at the synapse. The exact nature and structure of these chemical compounds can vary, but they all aim to enhance the activity or influence of neuroligin 1. Research into neuroligin 1 activators has expanded the understanding of synaptic biology and has provided insights into the molecular intricacies of neuronal communication. Given the pivotal role of neuroligin 1 in synaptic formation and maintenance, the study of these activators holds promise for unveiling deeper layers of neuronal function and connectivity in the nervous system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, a histone deacetylase (HDAC) inhibitor, is known to modulate gene expression. By inhibiting HDACs, it can lead to increased histone acetylation and potentially upregulate NLGN1 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can lead to the activation of CREB, a transcription factor that might upregulate NLGN1. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane can activate the Nrf2 pathway. Activation of this pathway might influence antioxidant responses and potentially increase NLGN1 expression indirectly. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has various cellular effects, including the activation of SIRT1 and AMPK pathways. These activations might influence synaptic proteins, including neuroligins. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin exhibits anti-inflammatory and antioxidant properties. Through its neuroprotective effects, it might influence synaptic proteins and increase NLGN1 expression. | ||||||
Levodopa | 59-92-7 | sc-205372 sc-205372A | 5 g 25 g | $53.00 $168.00 | 9 | |
L-DOPA is a precursor to dopamine. Increased dopamine levels in the brain might have downstream effects on synaptic proteins, potentially influencing NLGN1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major catechin in green tea, possesses antioxidant properties. It might influence neural protection and, in turn, modulate synaptic protein expressions including NLGN1. | ||||||