NELF-B Activators
NELF-B activators denote a series of compounds that have the potential to indirectly influence the NELF-B protein through the modulation of RNA polymerase II activity or the phosphorylation status of RNA polymerase II. This class of chemicals can be further categorized based on their specific targets and mechanisms of action. For instance, activators enact their influence by binding directly to RNA polymerase II and inhibiting its function. As the NELF-B protein forms a critical component of the NELF complex, which plays a significant role in pausing RNA polymerase II during transcription, the inhibition of RNA polymerase II can translate to an indirect influence on the NELF-B protein.
On the other hand, NELF-B activators class operate by inhibiting cyclin-dependent kinases (CDKs). These activators are characterized by their ability to alter the phosphorylation status of RNA polymerase II, thereby indirectly influencing NELF-B. Additionally, activators target and inhibit the protein BRD4. BRD4 is responsible for recruiting P-TEFb, a kinase essential for phosphorylating RNA polymerase II. The inhibition of BRD4 thus affects the recruitment of P-TEFb, indirectly influencing the function of NELF-B.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, which can lead to overall effects on transcription and therefore indirectly impact NELF-B. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits the activity of RNA polymerase II by covalently binding to a subunit of the enzyme, which can indirectly affect the function of NELF-B. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin binds and inhibits RNA polymerase II, impacting transcription and indirectly influencing NELF-B. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB inhibits RNA polymerase II, which can indirectly impact NELF-B due to its role in transcription regulation. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
Flavopiridol inhibits cyclin-dependent kinase 9 (CDK9) which phosphorylates RNA polymerase II, thus indirectly affecting NELF-B. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a CDK inhibitor that can indirectly affect NELF-B by altering the phosphorylation status of RNA polymerase II. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is a CDK inhibitor that affects RNA polymerase II activity, and thus can indirectly influence NELF-B. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Dinaciclib is a CDK inhibitor that can indirectly affect NELF-B by altering the phosphorylation status of RNA polymerase II. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits BRD4, a protein that recruits P-TEFb (a kinase that phosphorylates RNA polymerase II) which can indirectly impact NELF-B. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 inhibits BRD4, affecting the recruitment of P-TEFb and thus indirectly influencing NELF-B. | ||||||