NDUFAF3 Activators
NDUFAF3, standing for NADH:ubiquinone oxidoreductase complex assembly factor 3, is a protein that is instrumental in the assembly of mitochondrial complex I, also known as NADH:ubiquinone oxidoreductase. Complex I is the largest and first enzyme complex in the mitochondrial electron transport chain (ETC), which is a critical component of oxidative phosphorylation, the primary pathway through which eukaryotic cells convert nutrients into energy in the form of ATP.
The assembly and maintenance of complex I are intricate processes that require the coordination of various assembly factors. NDUFAF3 is one of these factors and is involved in the early stages of the assembly process. It plays a fundamental role in the assembly of the membrane arm and the stabilization of intermediate complex I assembly modules. Mutations in the NDUFAF3 gene have been associated with mitochondrial diseases, highlighting its essential role in proper cellular function and energy metabolism.NDUFAF3 functions within the mitochondria, where it interacts with other proteins and assembly factors to ensure the correct assembly and integration of the various subunits that constitute complex I. Complex I itself is composed of over 40 different subunits and is responsible for transferring electrons from NADH to coenzyme Q10 (ubiquinone) in the ETC, a process that contributes to the creation of a proton gradient across the mitochondrial inner membrane. This gradient is ultimately used to drive the synthesis of ATP by ATP synthase.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
A key component in the mitochondrial electron transport chain, possibly affecting NDUFAF3 by supporting complex I function. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $284.00 | ||
A derivative of Coenzyme Q10 targeted to mitochondria, potentially enhancing mitochondrial function and indirectly affecting NDUFAF3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Known to improve mitochondrial function, which could indirectly influence NDUFAF3 activity in complex I assembly. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
A coenzyme in redox reactions, crucial for mitochondrial function, potentially impacting NDUFAF3 indirectly. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
An anti-diabetic drug that improves mitochondrial function, potentially affecting NDUFAF3. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $238.00 | ||
Influences mitochondrial biogenesis, potentially affecting NDUFAF3. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
An antioxidant that affects mitochondrial metabolism, potentially impacting NDUFAF3. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A green tea polyphenol that may modulate mitochondrial function, possibly impacting NDUFAF3. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $27.00 $77.00 | 2 | |
Known to influence energy metabolism in mitochondria, potentially affecting NDUFAF3. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $40.00 $110.00 $515.00 | 3 | |
Involved in energy production and mitochondrial metabolism, could indirectly affect NDUFAF3. | ||||||